鳖甲煎丸联合恩替卡韦治疗高病毒载量慢性乙肝患者的疗效分析  

Efficacy Analysis of Biejiajian Pill Combined with Entecavir in the Treatment of 60 Cases of Chronic Hepatitis B Patients with High Viral Load

作　　者：王晓利[1] 赵俊君[1] 朱文刚[1] 仲小莉 WANG Xiaoli;ZHAO Junjun;ZHU Wengang;ZHONG Xiaoli(Puyang Center for Disease Control and Prevention,Puyang Henan 457000,China;Department of General Medicine,The Third People's Hospital of Puyang city,Puyang Henan 457000,China)

机构地区：[1]濮阳市疾病预防控制中心门诊部,河南濮阳457000 [2]濮阳市第三人民医院普内科,河南濮阳457000

出　　处：《临床研究》2022年第4期139-142,共4页Clinical Research

摘　　要：目的探讨高病毒载量慢性乙肝患者给予鳖甲煎丸联合恩替卡韦治疗的临床效果。方法选取2020年1月至2021年1月在濮阳市疾病预防控制中心治疗的60例高病毒载量慢性乙肝患者为研究对象,按照随机数字表法分成对照组(30例)和观察组(30例)。对照组给予恩替卡韦治疗,观察组给予鳖甲煎丸联合恩替卡韦治疗,比较两组患者乙肝病毒脱氧核糖核酸(HBV-DNA)阴转率、乙肝表面抗原(HBsAg)阴转率、肝功能、免疫功能及不良反应。结果观察组HBV-DNA阴转率、HBsAg阴转率明显高于对照组,差异有统计学意义(P<0.05)。治疗后,两组白蛋白(ALB)水平均明显提高,总胆红素(TBIL)、天冬氨酸转氨酶(AST)水平均明显降低,差异均有统计学意义(P<0.05);且观察组ALB水平较对照组明显更高,TBIL、AST水平明显更低,差异均有统计学意义(P<0.05)。治疗后,两组CD4^(+)、CD4^(+)/CD8^(+)明显提高,CD8^(+)明显降低,差异均有统计学意义(P<0.05);且观察组CD4^(+)、CD4^(+)/CD8^(+)较对照组明显更高,CD8^(+)明显更低,差异均有统计学意义(P<0.05)。观察组不良反应发生率较对照组明显更低,差异有统计学意义(P<0.05)。结论高病毒载量慢性乙肝患者给予鳖甲煎丸联合恩替卡韦治疗,能够提高HBV-DNA阴转率及HBsAg阴转率,改善肝功能及免疫功能,减少不良反应。Objective To investigate the clinical effect of Biejiajian pill combined with entecavir in the treatment of chronic hepatitis B patients with high viral load.Methods A total of 60 patients with chronic hepatitis B with high viral load who were treated in Puyang Center for Disease Control and Prevention from January 2020 to January 2021 were selected as the research objects,and they were divided into the observation group(30 cases)and the control group(30 cases)according to the random number table method.The control group was given entecavir treatment,the observation group was given Biejiajian pill combined with entecavir treatment.The negative conversion rate of hepatitis B virus deoxyribonucleic acid(HBV-DNA),hepatitis B surface antigen(HBsAg)negative conversion rate,liver function,immune function and adverse reactions.Results The HBV-DNA negative conversion rate and HBsAg negative conversion rate in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the levels of albumin(ALB)in the two groups were significantly increased(P<0.05),the levels of total bilirubin(TBIL)and aspartate aminotransferase(AST)were significantly decreased(P<0.05),the levels of ALB in the observation group were higher than those in the control group(P<0.05),the levels of TBIL and AST is significantly lower,the difference is statistically significant(P<0.05).After treatment,CD4^(+),CD4^(+)/CD8^(+)in the observation group were significantly increased(P<0.05),and CD8^(+)was significantly decreased(P<0.05),compared with the control group,CD4^(+)and CD4^(+)/CD8^(+)in the observation group were significantly higher,the difference was statistically significant(P<0.05),and CD8^(+)was significantly lower,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Biejiajian pills combined with entecavir therapy in patients with chronic hepatitis B with high viral load can i

关 键 词：鳖甲煎丸 恩替卡韦 高病毒载量 慢性乙肝 疗效 

分 类 号：R512.62[医药卫生—内科学]