金属有机骨架/聚乙烯醇双交联网络复合水凝胶的构建及其抗菌性能研究  

Fabrication of metal-organic framework/polyvinyl alcohol dual-crosslinked composite hydrogels and study on their antibacterial performance

作　　者：赵宁 汪伟[1,2] 谢锐 巨晓洁[1,2] 刘壮 褚良银[1,2] ZHAO Ning;WANG Wei;XIE Rui;JU Xiao-jie;LIU Zhuang;CHU Liang-yin(School of Chemical Engineering,Sichuan University,Chengdu 610065,China;State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China)

机构地区：[1]四川大学化学工程学院,四川成都610065 [2]四川大学高分子材料工程国家重点实验室,四川成都610065

出　　处：《现代化工》2022年第4期116-122,共7页Modern Chemical Industry

基　　金：国家自然科学基金(21922809)。

摘　　要：将具有抗菌性能的金属有机骨架(MOF)材料与具有双交联网络结构的聚乙烯醇(PVA)水凝胶相结合,构建了一种具有优良力学性能和抗菌性能的MOF/PVA抗菌水凝胶复合材料。该抗菌水凝胶采用物理与化学双交联的高分子网络结构,可增强水凝胶的力学性能。水凝胶内部结合了含有Ag^(+)的MOF(AMOF)颗粒和含有Zn^(2+)的MOF颗粒,随着2种MOF颗粒的缓慢降解,水凝胶持续释放的Ag^(+)和Zn^(2+)对细菌细胞造成物理损伤,实现对革兰氏阴性与阳性细菌生长的有效抑制,抑制率高达99%以上,为新型抗菌水凝胶材料的设计和构建提供了一种新策略。MOF/PVA antibacterial composite hydrogel is fabricated from dual-crosslinked polyvinyl alcohol(PVA)networks and antibacterial metal-organic frameworks(MOF).The hydrogel employs physically and chemically dual-crosslinked networks for enhanced mechanical performances.Meanwhile,the hydrogel contains Ag^(+)-containing MOF(A-MOF)and Zn^(2+)-containing MOF(ZMOF)nanoparticles.The hydrogel allows continuous release of Ag^(+)and Zn^(2+)via slow degradation of MOF nanoparticles,which causes physical damage to the bacteria,effectively inhibiting the growth of Gram-negative and Gram-positive bacteria with an inhibition ratio exceeding 99%.This work provides a new strategy for design and fabrication of novel antibacterial hydrogel materials.

关 键 词：水凝胶 金属有机骨架 双交联网络结构 抗菌 

分 类 号：TQ317[化学工程—高聚物工业]