双歧杆菌活菌辅助治疗对慢性腹泻患儿肠屏障功能、炎性因子及细胞免疫的影响  

Effects of live bifidobacteria adjuvant therapy on intestinal barrier function,inflammatory factors and cellular immunity in children with chronic diarrhea

作　　者：方秋月 文多花 付玲[3] FANG Qiu-yue;WEN Duo-hua;FU Ling(Department of Pediatrics,Guilin Maternal and Child Health Care Hospital,Guangxi 541000,Guilin;Department of Obstetrics,Guilin Maternal and Child Health Care Hospital,Guangxi 541000,Guilin;Department of Pediatrics,Hunan Maternal and Child Health Care Hospital,Changsha 410005,Hunan,China)

机构地区：[1]桂林市妇幼保健院儿科,广西桂林541000 [2]桂林市妇幼保健院产科,广西桂林541000 [3]湖南省妇幼保健院儿科,湖南长沙410005

出　　处：《川北医学院学报》2022年第4期465-468,共4页Journal of North Sichuan Medical College

基　　金：广西桂林市科学研究与技术开发计划项目(20190218-13-3)。

摘　　要：目的:探讨双歧杆菌活菌辅助治疗对慢性腹泻患儿肠屏障功能、炎性因子及细胞免疫的影响。方法:选取94例慢性腹泻患儿为研究对象,根据治疗方式不同分为研究组和对照组,每组各47例。对照组给予蒙脱石散治疗;研究组联合双歧杆菌三联活菌散治疗,疗程均为7 d。比较两组患儿治疗总有效率、肠屏障功能、各炎性因子及免疫指标水平。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组患儿二胺氧化酶、D-乳酸、内毒素及肠球菌水平低于对照组(P<0.05),乳杆菌与双歧杆菌水平高于对照组(P<0.05);IL-6、CRP及TNF-α水平低于对照组(P<0.05),IFN-γ及IL-10水平高于对照组(P<0.05);各免疫指标水平高于对照组(P<0.05)。结论:双歧杆菌活菌辅助治疗可有效抑制炎症反应,提高肠屏障功能及免疫功能,对促进慢性腹泻患儿病情康复有重要意义。Objective:To investigate the effects of live bifidobacterium adjuvant therapy on intestinal barrier function,inflammatory factors and cellular immunity in children with chronic diarrhea.Methods:94 cases of chronic diarrhea children were selected as the research objects,they were divided into research group and control group according to different treatment methods,with 47 cases in each group.Children in the control group were treated with montmorillonite powder,and children in the research group were treated with bifidobacterium triplex viable powder,the course of treatment was 7 days.The total effective rate,intestinal barrier function,inflammatory factors and immune indexes were compared between the two groups.Results:The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of diamine oxidase,D-lactic acid,endotoxin and enterococcus in the study group were significantly lower than those in the control group,while the levels of Lactobacillus and bifidobacteria were significantly higher than those in the control group(P<0.05).The levels of IL-6,CRP and TNF-α in the study group were significantly lower than those in the control group,while the levels of IFN-γ and IL-10 were significantly higher than those in the control group(P<0.05).The levels of immune indexes in the study group were significantly higher than those in the control group(P<0.05).Conclusion:Live bifidobacterium adjuvant therapy can effectively inhibit inflammatory response,improve intestinal barrier function and immune function,with definite curative effect,and has positive significance for promoting the rehabilitation of children with chronic diarrhea.

关 键 词：慢性腹泻 双歧杆菌活菌散 蒙脱石散 肠屏障功能 免疫功能 炎症因子 儿童 

分 类 号：R725.7[医药卫生—儿科]