来曲唑联合复方玄驹胶囊治疗少、弱精子症不育的临床研究  

Clinical study of Letrozole combined with compound Xuanju capsule in the treatment of oligospermia and asthenospermia infertility

作　　者：杨勇 王英男[1] 丁苏宁 杨文霞 全超[1] 宋明旭[1] Yang Yong;Wang Yingnan;Ding Suning;Yang Wenxia;Quan Chao;Song Mingxu(Affiliated hospital of Jiangnan University,Wuxi,Jiangsu,214000,China)

机构地区：[1]江南大学附属医院,江苏无锡214000

出　　处：《齐齐哈尔医学院学报》2022年第4期332-336,共5页Journal of Qiqihar Medical University

摘　　要：目的 评价来曲唑联合复方玄驹胶囊治疗少、弱精子症不育的疗效。方法 选择2019年1月—2020年5月在本院接受治疗的76例少、弱精子症不育患者为研究对象,随机分为来曲唑组和复方玄驹胶囊组两组,每组各38例。来曲唑组接受来曲唑治疗;复方玄驹胶囊组给予来曲唑联合复方玄驹胶囊治疗。比较两组的临床疗效、性激素水平、精液质量、不良反应和女方妊娠率。结果 复方玄驹胶囊组有效率为89.47%,高于来曲唑组的71.05%,差异有统计学意义(χ^(2)=4.070,P<0.05)。治疗前、后对比,来曲唑组FSH、T和LH水平较治疗前升高(t=15.336,4.127,13.547;P<0.05),复方玄驹胶囊组各性激素水平也较治疗前升高(t=17.563,8.824,16.039;P<0.05);治疗后对比,复方玄驹胶囊组各性激素水平均高于来曲唑组(t=3.096,3.915,3.390;P<0.05)。治疗前、后对比,来曲唑组的精液量、精子浓度、精子存活率、精子畸形率和前向运动百分率均较治疗前改善(t=3.648,11.133,12.303,3.220,17.047,6.262;P<0.05),复方玄驹胶囊组的上述各指标也均较治疗前改善(t=9.078,17.906,14.397,9.735,27.766,12.032;P<0.05);治疗后对比,复方玄驹胶囊组的上述各指标均明显优于来曲唑组(t=3.451,6.813,3.506,6.564,6.539,4.998;P<0.05)。来曲唑组与复方玄驹胶囊组不良反应发生率比较无统计学差异(7.89%vs 10.53%,χ^(2)=0.157,P>0.05)。复方玄驹胶囊组临床妊娠率为65.79%,大于来曲唑组的42.11%,差异均有统计学意义(χ^(2)=4.290,P<0.05)。结论 来曲唑联合复方玄驹胶囊治疗少、弱精子症不育的临床疗效确切,能够调节性激素水平,有效改善精液质量,提高女方妊娠率,且不良反应少,用药安全性高。值得临床推广使用。Objective To evaluate the efficacy of letrozole combined with compound Xuanju capsule inthe treatment of oligospermia and asthenospermia infertility.Methods A total of 76 patients suffered witholigospermia and asthenospermia infertility, those were treated in the affiliated hospital of Jiangnan University fromJanuary 2019 to May 2020, were selected as research objects, and they were randomly divided into letrozole groupand compound Xuanju capsule group, with 38 cases in each group. Patients in the letrozole group were treatedwith letrozole, while patients in the Compound Xuanju Capsule group received letrozole combined with CompoundXuanju Capsule. The clinical efficacy, sex horls, sperm quality, adverse reactions and pregnancy rate oftheir wives of the two groups were compared.Rmeosnuel tlseve The total clinical effective rate in the Compound XuanjuCapsule group was 89.47%, which was higher than 71.05% in the letrozole group, there was significant differencebetween the groups (χ^(2)= 4.070, P<0.05). The levels of follicle stimulating hormone, testosterone and luteinizinghormone in the letrozole group were higher than those before treatment(t= 15.336, 4.127, 13.547;P<0.05),and the levels of follicle stimulating hormone, testosterone and luteinizing hormone in the Compound XuanjuCapsule group were also higher than those before treatment(t= 17. 563, 8. 824, 16. 039;P< 0. 05). After treatment, the levels of follicle stimulating hormone, testosterone and luteinizing hormone in the CompoundXuanju Capsule group were higher than those in the letrozole group(t= 3.096, 3.915, 3.390;P<0.05). Thesemen volume, sperm concentration, sperm survival rate, sperm deformity rate and forward movement percentagein the letrozole groPup were improved compared with those before treatment(t= 3.648, 11.133, 12.303, 3.220,17.047, 6. 262;< 0. 05). The above indexes in the Compound Xuanju Capsule group were also improvedcompared with before treatment(t= 9.078, 17.906, 14.397, 15.917, 9.735, 12.032;P<0.05). After treatment,the above indexes i

关 键 词：来曲唑 复方玄驹胶囊 少、弱精子症 临床疗效 

分 类 号：R698.2[医药卫生—泌尿科学]