Cohesion mechanisms for bioadhesives  

作　　者：Yazhong Bu Abhay Pandit 

机构地区：[1]Institute of Medical Engineering,Department of Biophysics,School of Basic Medical Sciences,Health Science Center,Xi’an Jiaotong University,Xi’an,710061,China [2]CÚRAM,SFI Research Centre for Medical Devices National University of Ireland,Galway,Ireland

出　　处：《Bioactive Materials》2022年第7期105-118,共14页生物活性材料（英文）

基　　金：The authors would like to acknowledge the Science Foundation Ireland(SFI)and the European Regional Development Fund(Grant Number 13/RC/2073_P2)for financial assistance;YB is supported by funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 713690.

摘　　要：Due to the nature of non-invasive wound closure,the ability to close different forms of leaks,and the potential to immobilize various devices,bioadhesives are altering clinical practices.As one of the vital factors,bioadhesives’strength is determined by adhesion and cohesion mechanisms.As well as being essential for adhesion strength,the cohesion mechanism also influences their bulk functions and the way the adhesives can be applied.Although there are many published reports on various adhesion mechanisms,cohesion mechanisms have rarely been addressed.In this review,we have summarized the most used cohesion mechanisms.Furthermore,the relationship of cohesion strategies and adhesion strategies has been discussed,including employing the same functional groups harnessed for adhesion,using combinational approaches,and exploiting different strategies for cohesion mechanism.By providing a comprehensive insight into cohesion strategies,the paper has been integrated to offer a roadmap to facilitate the commercialization of bioadhesives.

关 键 词：BIOADHESIVE COHESION HYDROGEL Medical device fixation SEALANT 

分 类 号：R318[医药卫生—生物医学工程]