痰热清注射液联合莫西沙星注射液治疗老年社区获得性肺炎的临床效果及对血清炎性因子的影响  

Clinical efficacy of Tanreqing injection combined with moxifloxacin injection in treatment of elderly patients with community acquired pneumonia and influence on serum inflammatory factors

作　　者：庄海涛 许洋 ZHUANG Haitao;XU Yang(Linyi Central Hospital,Shandong Province,Linyi 276400,China)

机构地区：[1]山东省临沂市中心医院,276400

出　　处：《临床合理用药杂志》2022年第11期13-16,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察痰热清注射液联合莫西沙星注射液治疗老年社区获得性肺炎的临床效果及对炎性因子的影响。方法选取2019年1月—2020年10月临沂市中心医院收治的老年社区获得性肺炎患者84例为研究对象,根据随机分数字表法分为观察组和对照组,每组42例。常规综合治疗基础上,对照组给予莫西沙星注射液治疗,观察组在对照组基础上给予痰热清注射液治疗,2组均持续治疗10 d。比较2组患者临床疗效、临床症状改善时间,治疗前后血清肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)、C反应蛋白(CRP)水平及不良反应。结果观察组患者治疗总有效率为97.62%,高于对照组的78.57%(χ^(2)=7.265,P=0.007);观察组患者发热消失时间、咳嗽消失时间及啰音消失时间均短于对照组(P<0.01);治疗10 d后,2组CRP、PCT及TNF-α水平均较治疗前降低,且观察组低于对照组(P均<0.01);2组药物不良反应发生率(9.52%vs.4.76%)比较差异无统计学意义(χ^(2)=0.179,P>0.05)。结论痰热清注射液联合莫西沙星注射液治疗老年社区获得性肺炎临床效果良好,能明显降低患者血清炎性因子水平,安全性较高,值得临床推广应用。Objective To investigate the clinical efficacy of Tanreqing injection combined with moxifloxacin injection in the treatment of elderly patients with community acquired pneumonia and influence on serum inflammatory factors.Methods A total of 84 elderly patients with community acquired pneumonia who were admitted to Linyi Central Hospital from January 2019 to October 2020 were selected as the research objects,and divided into an observation group and a control group according to the random number table method,with 42 cases in each group.The patients in both groups were treated by conventional therapy.The control group was given moxifloxacin injection on the basis of the conventional therapy,while the observation group was treated with Tanreqing injection on the basic of the control group.Treatment course was 10 days for both groups.The clinical efficacy,the time of improvement of clinical symptoms and the adverse reaction were compared between the two groups.The levels of serum tumor necrosis factor-α(TNF-α),procalcitonin(PCT)and C-reactive protein(CRP)were compared between the two groups before and after treatment.Results The total effective rate of the observation group was 97.62%,which was significantly higher than 78.57% of the control group(χ^(2)=7.265,P=0.007).The disappearance time of fever,cough and rales in the observation group were shorter than those in the control group(P<0.01).After 10 days of treatment,the levels of serum TNF-α,PCT and CRP of the two groups significantly lower than those before treatment,and the above indexes of the observation group were significantly lower than those of the control group(all P<0.01).The incidence rate of adverse reactions was 9.52% in the observation group and 4.76% in the control group.There was no significant difference in the incidence rate of adverse reactions between the two groups(χ^(2)=0.179,P>0.05).Conclusion Tanreqing injection combined with moxifloxacin injection in the treatment of elderly patients with community acquired pneumonia has good clinical

关 键 词：老年社区获得性肺炎 痰热清注射液 莫西沙星注射液 临床效果 炎性因子 

分 类 号：R563.1[医药卫生—呼吸系统]