舒巴坦钠联合氨苄西林钠治疗小儿肺部感染的临床效果  

Clinical effect of sulbactam sodium combined with ampicillin sodium in the treatment of pulmonary infection in children

作　　者：李渊 LI Yuan(Department of Pediatrics,Nanzhang County People's Hospital,Hubei Province,Nanzhang County 441500,China)

机构地区：[1]湖北省南漳县人民医院儿科,441500

出　　处：《临床合理用药杂志》2022年第11期28-30,35,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察氨苄西林钠联合舒巴坦钠治疗小儿肺部感染的临床效果。方法选取2018年5月—2020年5月湖北省南漳县人民医院收治的小儿肺部感染患儿52例,采用“抓阄法”随机分为观察组和对照组,各26例。在常规治疗基础上,对照组予注射用氨苄西林钠治疗,观察组在对照组基础上加用注射用舒巴坦钠治疗,2组患儿均治疗1周。比较2组治疗效果、症状改善(止咳、退热、心率呼吸复常、病灶吸收、肺部啰音消失)时间,治疗前后炎性因子[白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平变化。结果观察组治疗总有效率为92.31%,高于对照组的61.54%(χ^(2)=6.933,P=0.008);观察组止咳、退热、心率呼吸复常、病灶吸收、肺部啰音消失时间均短于对照组(P<0.01);治疗1周后,2组IL-6、IL-8、TNF-α水平均较治疗前降低,且观察组低于对照组(P<0.05或P<0.01)。结论氨苄西林钠联合舒巴坦钠治疗小儿肺部感染效果显著,可提高治疗有效率,缩短患儿症状消失、病灶吸收及体征恢复正常时间,并可有效控制炎性因子水平,值得临床推广应用。Objective To observe the clinical effect of sulbactam sodium combined with ampicillin sodium in the treatment of pulmonary infection in children.Methods Fifty-two children with pulmonary infection treated in Nanzhang County People's Hospital of Hubei Province from May 2018 to May 2020 were randomly divided into observation group and control group by“lot drawing method”,with 26 cases in each group.On the basis of routine treatment,the control group was treated with ampicillin sodium for injection,and the observation group was treated with sulbactam sodium for injection on the basis of the control group.Both groups were treated for 1 week.The treatment effect,the time of symptom improvement(cough relief,fever relief,normalization of heart rate and respiration,focus absorption and disappearance of pulmonary rales)and the changes of inflammatory factors(IL-6,IL-8 and TNF-α)before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 92.31%,higher than 61.54% of the control group(χ^(2)=6.933,P=0.008).The time of relieving cough,relieving fever,normalizing heart rate and respiration,focal absorption and disappearance of pulmonary rales in the observation group were shorter than those in the control group(all P<0.01).After one week of treatment,the levels of IL-6,IL-8 and TNF-α in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group(P<0.05 or P<0.01).Conclusion Sulbactam sodium Combined with ampicillin sodium is effective in the treatment of pulmonary infection in children.It can improve the treatment efficiency and shorten the time for the disappearance of symptoms,the absorption of lesions and the recovery of signs.It can also effectively control the level of inflammatory factors,which is worthy of clinical application.

关 键 词：小儿肺部感染 舒巴坦钠 氨苄西林钠 临床效果 

分 类 号：R725.6[医药卫生—儿科]