生物活性肽组合物缓解小鼠体力疲劳的作用研究  

The Alleviative Effect of Bioactive Peptide Composition on Physical Fatigue in Mice

作　　者：沈起兵 刘丽燕 刘同方 李亦凡 曾萍 李淑娟 张国文 张翼飞 于燕波 SHEN Qi-bing;LIU Li-yan;LIU Tong-fang(Space Science and Technology Institute(Shenzhen),Shenzhen,Guangdong 518117;Lee Kum Kee(Xin Hui)Food Co.,Ltd.,Jiangmen,Guangdong 529156)

机构地区：[1]深圳市绿航星际太空科技研究院,广东深圳518117 [2]李锦记(新会)食品有限公司,广东江门529156

出　　处：《安徽农业科学》2022年第8期137-140,共4页Journal of Anhui Agricultural Sciences

基　　金：3D航天食品打印技术及功能性调味品联合实验室科技项目(SP20180530011);深圳市科技计划项目(JCYJ20180507182854651)。

摘　　要：[目的]研究生物活性肽组合物缓解体力疲劳的作用及机制。[方法]KM小鼠随机分为空白对照组(NC组)、模拟疲劳对照组(FC组)和模拟疲劳生物活性肽组合物处理组(FS组)。FC、FS组小鼠每天进行负重游泳制备疲劳应激模型,连续29 d,NC组不作处理。FS组小鼠每天灌胃相应浓度的生物活性肽组合物,1次/d,连续30 d;NC组和FC组同法灌胃去离子水。末次灌胃30 min后,分别进行负重游泳时间试验、血清尿素氮试验、肝糖原试验、血乳酸试验和红细胞携氧能力试验。[结果]与NC组比较,FC组的血清尿素氮浓度升高(P<0.05);与FC组比较,FS组负重游泳时长增加(P<0.05),血清尿素氮含量降低(P<0.05),血乳酸曲线下面积下降(P<0.01)。[结论]生物活性肽组合物具有一定的增强运动耐力和缓解体力疲劳作用。[Objective]To investigate the alleviating physical fatigue effect of bioactive peptide composition and its mechanism.[Method]KM mice were randomly divided into a blank control group(NC group),simulated fatigue control group(FC group),and experimental group(FS group).Mice in FC group and FS group were subjected to loaded swimming every day to prepare fatigue model for 29 consecutive days,while those in NC group were not treated.Mice in FS group were given intragastric administration of the corresponding concentration of bioactive peptide composition once a day for 30 consecutive days,while those in NC group and FC group were given intragastric administration of deionized water.Loaded swimming time,serum BUN,hepatic glycogen,area under the curve of blood lactic acid and oxygen carrying capacity of erythrocytes were measured at 30 minutes after the last intragastric administration.[Result]Compared with NC group,serum BUN in FC group was increased(P<0.05),compared with FC group,the bioactive peptide composition could observably increase the loaded swimming time(P<0.05)and decrease serum BUN(P<0.05)and blood lactic acid(P<0.01).[Conclusion]The bioactive peptide composition could increase athletic stamina and has an anti-fatigue effect.

关 键 词：生物活性肽组合物 缓解体力疲劳 负重游泳 血清尿素氮 血乳酸 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]