基于响应面法的甘松挥发油提取工艺优化研究  

Study on Optimization of Extraction Process of Volatile Oil from Nardostachyos Radix et Rhizoma Based on Response Surface Methodology

作　　者：杨祎辰 王二欢 王继强 党艳妮 唐茜琳 常晖 靳鹏博 马存德 YANG Yi-chen;WANG Er-huan;WANG Ji-qiang(Shaanxi Institute of International Trade&Commerce,Xianyang,Shaanxi 712046;Shaanxi Buchang Pharmaceutical Co.,Ltd.,Xi’an,Shaanxi 710075)

机构地区：[1]陕西国际商贸学院,陕西咸阳712046 [2]陕西步长制药有限公司,陕西西安710075

出　　处：《安徽农业科学》2022年第8期152-155,共4页Journal of Anhui Agricultural Sciences

基　　金：陕西省重点研发计划(2022SF-575);2019年医疗服务与保障能力提升补助资金项目(财社〔2019〕39号)。

摘　　要：[目的]优化甘松挥发油的提取工艺。[方法]通过单因素试验考察粒径、料液比、浸泡时间和提取时间对甘松挥发油含量的影响,选定工艺参数和变化水平。采用Box-Benhnken响应面法,以甘松挥发油含量为评价指标,建立数学回归模型。[结果]粒径527μm、料液比1∶10.2(g∶mL)、提取时间10.9 h为最佳提取工艺,挥发油含量为4.12%。[结论]在该条件下甘松挥发油提取稳定、可靠。[Objective]To optimize the extraction process of volatile oil of Nardostachyos Radix et Rhizoma.[Method]The single factor experiment was used to investigate the influence of particle size,solid-liquid ratio,soaking time and extraction time on the volatile oil content of Nardostachyos Radix et Rhizoma,and the process parameters and change levels were selected.The Box-Benhnken response surface method was used to establish a mathematical regression model with the volatile oil content of Nardostachyos Radix et Rhizoma as the evaluation index.[Result]527μm particle size,1∶10.2(g∶mL)solid-liquid ratio,and 10.9 h extraction time were the best extraction processes.Under these conditions,the volatile oil content was 4.12%.[Conclusion]Under this condition,the extraction of volatile oil from Nardostachyos Radix et Rhizoma was stable and reliable.

关 键 词：甘松 挥发油 响应面法 提取工艺 优化 

分 类 号：R284.2[医药卫生—中药学]