葡萄球菌感染肺炎患儿血清CRP、PCT水平变化及临床意义  

Changes of Serum CRP and PCT Levels in Children with Pneumonia Caused by Staphylococcus Infection and Their Clinical Significance

作　　者：张军 ZHANG Jun(Department of Pediatrics,Xianning Maternal and Child Health Hospital,Xianning,Hubei province,437199 China)

机构地区：[1]咸宁市妇幼保健院儿科,湖北咸宁437199

出　　处：《系统医学》2022年第2期151-154,共4页Systems Medicine

摘　　要：目的探讨葡萄球菌感染肺炎患儿血清C反应蛋白(CRP)和降钙素原(PCT)水平变化的临床意义。方法选取该院2020年7月—2021年7月接收和治疗的葡萄球菌感染肺炎患儿50例(研究组),再选取同一时间段的非肺炎患儿50例(参照组)作为研究对象,对比两组患儿的临床指标。结果研究组炎症因子水平[CRP(14.66±2.35)ng/L、白细胞介素8(IL-8)(120.37±5.77)ng/L、PCT(35.62±1.35)ng/L]明显高于参照组,差异有统计学意义(t=9.821、14.905、44.151,P<0.05);研究组脑脊液酸碱性指标pH值(7.31±0.25)、血氧分压(PO_(2))(63.01±1.22)mmHg、血二氧化碳分压(PCO_(2))(72.03±3.42)mmHg相较于对照组,差异有统计学意义(t=3.501、5.695、71.433,P<0.05)。肺炎患儿与CRP、PCT、PCO_(2)等因素与其葡萄球菌感染肺炎之间为正相关(P<0.05)。结论CRP和PCT均在葡萄球菌感染中具有明显表现,与患者疾病有明显的相关性,对儿童葡萄球菌感染的诊断和治疗有一定的借鉴作用。Objective To investigate the changes of serum C-reactive protein(CRP)and procalcitonin(PCT)levels in children with staphylococcal pneumonia and their clinical significance.Methods 50 children with staphylococcal pneumonia received and treated in the hospital from July 2020 to July 2021(study group)and 50 children without pneumonia during the same period(reference group)were selected as the study objects,and the clinical indicators in the two groups were compared.Results The levels of inflammatory factors[CRP(14.66±2.35)ng/L,interleukin 8(IL-8)(120.37±5.77)ng/L,PCT(35.62±1.35)ng/L]in the study group were significantly higher than those in the control group,and the differences were statistically significant(t=9.821,14.905,44.151,P<0.05).The pH values of cerebrospinal fluid(7.31±0.25),partial pressure of oxygen(PO_(2))(63.01±1.22)mmHg and partial pressure of carbon dioxide(PCO_(2))(72.03±3.42)mmHg in the study group were better than those in the control group,and the differences were statistically significant(t=3.501,5.695,71.433,P<0.05).There was positive correlation between CRP,PCT,PCO_(2) and staphylococcal pneumonia in children with pneumonia(P<0.05).Conclusion Both CRP and PCT have obvious expression in staphylococcal infection,and have obvious correlation with the patient's disease,which can be used for reference in the diagnosis and treatment of staphylococcal infection in children.

关 键 词：葡萄球菌感染 小儿肺炎 CRP PCT 

分 类 号：R563.1[医药卫生—呼吸系统]