分析达英-35配合促排卵法治疗多囊卵巢综合征不孕的效果及妊娠结局影响  

Analysis on the Effect of Diaing-35 Combined with Ovulation-inducing Therapy in the Treatment of Infertility with Polycystic Ovary Syndrome and the Influence of Pregnancy Outcome

作　　者：樊爱法 FAN Aifa(Department of Gynecology,Feixian People's Hospital,Linyi,Shandong Province,273400 China)

机构地区：[1]山东费县人民医院妇科,山东临沂273400

出　　处：《系统医学》2022年第2期167-170,共4页Systems Medicine

摘　　要：目的对多囊卵巢综合征不孕患者开展研究,对其临床情况进行分析,以期明确达英-35配合促排卵法方案的价值效果。方法选取该院2018年1月—2020年1月收治的多囊卵巢综合征不孕患者96例开展研究,根据随机数字表法分为对照组、观察组,各48例。对照组单独使用达英-35,观察组则联合使用达英-35、促排卵法,通过比较总有效率、超声参数变化(子宫体积、子宫内膜厚度),以及血清性激素水平-雌二醇(estradiol,E_(2))、促卵泡生成激素(follicle-stimulating hormone,FSH)、促黄体生成素(luteinising hormone,LH)及妊娠结局(妊娠率)等指标变化。结果用药后,观察组总有效率95.83%较对照组75.00%高,差异有统计学意义(χ^(2)=8.362,P<0.05);观察组血清LH、FSH水平较对照组低,差异有统计学意义(t=3.630、4.491,P<0.05);观察组子宫体积、子宫内膜厚度变化较对照组改善显著,差异有统计学意义(t=2.001、3.739,P<0.05);观察组不良反应发生率为4.17%较对照组的16.67%低,但妊娠率85.42%高于对照组的66.67%,差异有统计学意义(χ^(2)=4.019、4.631,P<0.05)。结论对多囊卵巢综合征不孕患者采用达英-35配合促排卵法方案,可强化治疗效果,调节血清性激素水平,改善子宫体积、子宫内膜厚度,进而提高妊娠率,减少不良反应。Objective To select infertile patients with polycystic ovary syndrome to carry out research and analyze their clinical conditions,in order to clarify the value and effect of Diane-35 combined with ovulation stimulation program.Methods 96 infertile patients with polycystic ovary syndrome treated in the hospital from January 2018 to January 2020 were selected for the study.They were randomly divided into control group and observation group,with 48 cases in each group.The control group used Diane-35 alone,the observation group used Diane-35,ovulation induction method,compared the total effective rate,changes in ultrasound parameters(uterine volume,endometrial thickness),and serum sex hormone levels-estradiol(E_(2)),follicle-stimulating hormone(FSH),luteinising hormone(Luteinising Hormone,LH)and pregnancy outcome(pregnancy rate)and other indicators.Results After medication,the total effective rate of the observation group was 95.83%higher than that of the control group 75.00%,and the difference was statistically significant(χ^(2)=8.362,P<0.05).Serum LH and FSH levels in the observation group were lower than those in the control group,and the difference was statistically significant(t=3.630,4.491,P<0.05).The changes of uterine volume and endometrial thickness in the observation group were significantly improved compared with those in the control group,and the difference was statistically significant(t=2.001,3.739,P<0.05).The incidence of adverse reactions in the observation group was 4.17%lower than that in the control group 16.67%,but the pregnancy rate was 85.42%higher than that in the control group 66.67%,and the difference was statistically significant(χ^(2)=4.019,4.631,P<0.05).Conclusion The use of Diane-35 combined with ovulation stimulation program for infertility patients with polycystic ovary syndrome can strengthen the therapeutic effect,regulate the level of serum sex hormones,and improve the volume of the uterus and the thickness of the endometrium.This will increase the pregnancy rate and reduce adverse

关 键 词：多囊卵巢综合征 不孕 达英-35 促排卵法 血清性激素水平 妊娠结局 

分 类 号：R59[医药卫生—内科学]