手性拆分技术在药物研发中的研究进展及应用  

Research Progress and Application of Chiral Resolution Technology in Drug Research and Development

作　　者：马玉恒 孙威 唐潇洒 朱淼淼 黄静 杨月 王文龙 MA Yu-heng;SUN Wei;TANG Xiao-sa;ZHU Miao-miao;HUANG Jing;YANG Yue;WANG Wen-long(Department of Pharmaceutical Engineering,School of Materials and Chemical Engineering,Chuzhou University,Chuzhou 239000,China)

机构地区：[1]滁州学院材料与化学工程学院制药工程系,安徽滁州239000

出　　处：《安徽化工》2022年第2期3-5,10,共4页Anhui Chemical Industry

基　　金：滁州学院校启动基金(2020qd09)资助;安徽省大学生创新创业训练计划项目(S202010377119)资助。

摘　　要：手性药物是指药物分子具有对映异构体的一类药物,其不同的异构体在生物体内可能有不同作用。相比于消旋体,手性对映体药物有更高活性和更小的毒副作用,因此,如何获得高纯度手性单体备受关注。介绍了几种经典手性物质拆分法,包括结晶拆分法、生物拆分法、化学拆分法、色谱拆分法、毛细管电泳法、膜分离法,梳理了各类方法优缺点并对手性拆分技术未来发展方向进行了展望。Chiral drugs refer to a class of drugs whose drug molecules have enantiomers. Different isomers may have different effects in organisms. Compared with racemates, chiral enantiomers have higher activity and less toxic and side effects.Therefore, how to obtain high-purity chiral monomers has attracted much attention. This paper introduces several classical chiral resolution methods, including crystal resolution, biological resolution, chemical resolution, chromatographic resolution, capillary electrophoresis and membrane separation, and combs the advantages, disadvantages and future prospects of various methods.

关 键 词：手性分子 结晶拆分法 生物拆分法 化学拆分法 色谱拆分法 

分 类 号：TQ460.1[化学工程—制药化工]