Carbon Dots as Artificial Peroxidases for Analytical Applications  

作　　者：Shih-Chun Wei Yang-Wei Lin Huan-Tsung Chang 

机构地区：[1]Department of Chemistry,National Taiwan University,Taipei 10617,Taiwan [2]Department of Chemistry,National Changhua University of Education,Changhua 50017,Taiwan [3]Department of Chemistry,Chung Yuan Christian University,Taoyuan City 32023,Taiwan

出　　处：《Journal of Analysis and Testing》2019年第3期191-205,共15页分析检测（英文）

基　　金：We are grateful to the Ministry of Science and Technology(MOST)of Taiwan for providing financial support for this study under contracts 107-2113-M-002-015-MY3,and MOST 107-2113-M-018-005.

摘　　要：Nanozymes have become attractive in analytical and biomedical fields,mainly because of their low cost,long shelf life,and less environmental sensitivity.Particularly,nanozymes formed from nanomaterials having high surface area and rich active sites are interesting since their activities can be tuned through carefully controlling their size,morphology,and surface properties.This review article focuses on preparation of carbon dots(C dots)possessing peroxidase-like activity and their analytical applications.We highlight the important roles of the oxidation states and surface residues of C dots and their nanocomposites with metal,metal oxides,or metal sulfides playing on determining their specificity and sensitivity toward H2O2.Examples of C dot nanozymes(CDzymes)for developing sensitive and selective absorption,fluorescence,and elec-trochemical sensing systems in the presence of substrates are presented to show their potential in analytical applications.For example,CDzymes couple with glucose oxidase and cholesterol oxidase are specific and sensitive for quantitation of glucose and cholesterol,separately,when using 3,3′,5,5′-tetramethylbenzidine(TMB)as the signal probe.This review article concludes with possible strategies for enhancing and tuning the catalytic activity of CDzymes.

关 键 词：Nanozymes PEROXIDASE Carbon dots CDzymes SENSING 

分 类 号：R52[医药卫生—内科学]