关节软骨表面粗糙度对载荷响应的实验研究  

Experimental study of the response of articular cartilage surface roughness to load

作　　者：门玉涛[1,2] 刘凯丰 刘福龙 张春秋[1,2] MEN Yutao;LIU Kaifeng;LIU Fulong;ZHANG Chunqiu(Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control,School of Mechanical Engineering,Tianjin University of Technology,Tianjin 300384,P.R.China;National Demonstration Center for Experimental Mechanical and Electrical Engineering Education(Tianjin University of Technology),Tianjin 300384,P.R.China)

机构地区：[1]天津理工大学天津市先进机电系统设计与智能控制重点实验室,天津300384 [2]机电工程国家级实验教学示范中心(天津理工大学),天津300384

出　　处：《生物医学工程学杂志》2022年第2期347-352,共6页Journal of Biomedical Engineering

基　　金：天津市自然科学基金(18JCYBJC95200);国家自然科学基金(12072235);天津市科技支撑重点项目(19YFZCCG00410);天津科技计划项目(19YFZCSN01150)。

摘　　要：软骨表面纤维化是骨关节炎的早期迹象,软骨表面损伤与载荷密切相关。本文目的是研究软骨表面粗糙度与载荷之间的关系,通过对新鲜的猪关节软骨施加冲击、压缩、疲劳载荷,每次间隔10 min测量软骨表面粗糙度数值,获得粗糙度在加载前后的变化规律。实验发现,载荷使软骨表面粗糙度增大,增大的数值与载荷大小相关,粗糙度恢复到初始情况的时间与载荷类型和载荷大小相关,冲击载荷对软骨表面粗糙度影响最大,其次是重度疲劳载荷、压缩载荷和轻度疲劳载荷。本文为揭示早期骨关节炎的发病机制和防治关节软骨疾病提供了参考数据。Cartilage surface fibrosis is an early sign of osteoarthritis and cartilage surface damage is closely related to load. The purpose of this study was to study the relationship between cartilage surface roughness and load. By applying impact, compression and fatigue loads on fresh porcine articular cartilage, the rough value of cartilage surface was measured at an interval of 10 min each time and the change rule of roughness before and after loading was obtained. It was found that the load increased the roughness of cartilage surface and the increased value was related to the load size. The time of roughness returning to the initial condition was related to the load type and the load size. The impact load had the greatest influence on the roughness of cartilage surface, followed by the severe fatigue load, compression load and mild fatigue load. This article provides reference data for revealing the pathogenesis of early osteoarthritis and preventing and treating articular cartilage diseases.

关 键 词：关节软骨 表面粗糙度 载荷 磨损 

分 类 号：R684.3[医药卫生—骨科学]