血清25-羟基维生素D水平的变化与妊娠期糖尿病孕妇糖代谢的相关性分析  

Correlation Analysis of Serum 25-Hydroxy-vitamin D Level and Glucose Metabolism in Pregnant Women with Gestational Diabetes Mellitus

作　　者：张静[1] 石祥奎 姜英凤[1] 黄亭 刘源[1] 曹政[1] 黄辉 唐文明 ZHANG Jing;SHI Xiang-kui;JIANG Ying-feng;HUANG Ting;LIU Yuan;CAO Zheng;HUANG Hui;TANG Wen-ming(Xuzhou Maternal and Child Health Hospital,Xuzhou Jiangsu 221009,China;Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Suzhou Jiangsu 215000,China)

机构地区：[1]徐州市妇幼保健院,江苏徐州221009 [2]苏州中西医结合医院,江苏苏州215000

出　　处：《抗感染药学》2022年第1期36-40,共5页Anti-infection Pharmacy

基　　金：江苏省药学会项目(编号:H202046)。

摘　　要：目的:分析妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇血清25-维生素D水平的变化与糖代谢的相关性。方法:分别抽取医院2018年9月—2019年8月产检的妊娠期糖尿病孕妇230例(GDM组)和正常妊娠期组(NGP组)孕妇353例资料,比较其采用免疫层析法分别检测的血清25-羟基维生素D水平的差异,分析2组孕妇25-羟基维生素D水平检测结果对糖代谢的影响。结果:妊娠期血清25-羟基维生素D水平均较低,小于35岁年龄组孕妇血清25-羟基维生素D水平为(46.277±9.839)mmol/L,大于或等于35岁年龄组孕妇血清25-羟基维生素D水平为(47.394±10.540)mmol/L,均为缺乏状态;妊娠期孕妇25-羟基维生素D的代谢随季节变化产生波动,而春、夏、秋、冬季血清25-羟基维生素D平均水平分别测得(44.203±7.917)mmol/L(、49.065±11.029)mmol/L、(49.171±11.142)mmol/L和(44.652±8.854)mmol/L,在夏、秋季25-羟基维生素D水平相对高于春、冬季;GDM组孕妇25-羟基维生素D水平明显低于NGP组,但经比较其差异无统计学意义(P>0.05);GDM组孕妇维生素25-羟基维生素D缺乏的比例更高,当25-羟基维生素D水平低于50 mmol/L时,GDM的风险显著升高;而当25-羟基维生素D水平高于75 mmol/L时,GDM的风险显著下降。结论:除季节因素外,糖代谢受血清25-羟基维生素D水平的影响,而血清25-羟基维生素D水平又与GDM风险相关;当血清25-羟基维生素D水平大于75 mmol/L时,GDM的风险明显下降。因此,了解我国孕妇血清25-羟基维生素D水平变化情况,有利于孕期合理补充维生素D,预防妊娠期糖尿病的发生。Objective:To analyze the correlation between serum 25-hydroxyvitamin D level and glucose metabolism in pregnant women with gestational diabetes mellitus(GDM).Methods:From September 2018 to August 2019,230pregnant women with gestational diabetes mellitus(GDM group)and 353 pregnant women with normal pregnancy(NGP group)were selected to compare the difference of serum 25-hydroxyvitamin D levels detected by immunochromatography.The effect of 25-hydroxyvitamin D level on glucose metabolism was analyzed.Results:The serum 25-hydroxyvitamin D level was(46.277±9.839)mmol/L in pregnant women younger than 35 years old,and was(47.394±10.540)mmol/L in pregnant women with age greater than or equal to 35 years,all of them were deficient.The metabolism of 25-hydroxyvitamin D fluctuated seasonally during pregnancy.The average levels of serum 25-hydroxyvitamin D in spring,summer,autumn and winter were(44.203±7.917)mmol/L,(49.065±11.029)mmol/L,(49.171±11.142)mmol/L and(44.652±8.854)mmol/L,respectively.The 25-hydroxyvitamin D levels in summer and autumn were higher than those in spring and winter.The level of 25-hydroxyvitamin D in GDM group was significantly lower than that in NGP group,but the difference was not statistically significant(P>0.05).The proportion of pregnant women with vitamin 25-hydroxyvitamin D deficiency was higher in the GDM group,and the risk of GDM was significantly increased when the 25-hydroxyvitamin D level was lower than 50 mmol/L.The risk of GDM decreased significantly when the 25-hydroxyvitamin D level was higher than 75 mmol/L.Conclusion:Apart from seasonal factors,glucose metabolism is affected by serum 25-hydroxyvitamin D level which is associated with the risk of GDM.When serum 25-hydroxyvitamin D level is greater than 75 mmol/L,the risk of GDM decreases significantly.Therefore,understanding the changes of serum 25-hydroxyvitamin D level in pregnant women is conducive to reasonable supplementation of vitamin D during pregnancy and prevention of gestational diabetes.

关 键 词：25-羟基维生素D 妊娠期糖尿病 糖代谢 相关性 

分 类 号：R969.3[医药卫生—药理学]