某院2020年220例药物不良反应报告的临床特征分析  

Analysis of Clinical Characteristics of 220 Cases of Adverse Drug Reactions in a Hospital in 2020

作　　者：陈栋 颜鲁青[1] CHEN Dong;YAN Lu-qing(Qinghai Provincial People's Hospital,Xining 810007 China)

机构地区：[1]青海省人民医院,西宁810007

出　　处：《抗感染药学》2022年第1期120-124,共5页Anti-infection Pharmacy

摘　　要：目的:分析医院2020年药物不良反应(adverse drug reactions,ADRs)的发生特点和规律,为临床安全用药提供参考。方法:采用回顾性研究方法,选取青海省人民医院2020年收集上报的220例ADRs病例报告,分析与评价ADRs的发生特点和规律。结果:220例ADRs发生患者中,男-女之比为1∶0.83,主要发生在50岁以上年龄段人群中(占72.72%),且主要发生在住院患者中,其中>40~50岁年龄段占15.45%;涉及的药品以抗肿瘤药物和抗菌药物为主(分别占26.36%和17.27%);ADRs涉及的临床表现以皮肤及其附件的损害和消化系统损害为主(分别占25.00%和24.55%),涉及的药品剂型与给药途径以注射剂(占60.00%)和静脉给药(占54.55%)为主。结论:临床应重点关注与监测抗肿瘤药物和静脉用抗菌药物的安全使用,加强对合理用药知识的宣传,提高合理用药水平。Objective:To analyze the characteristics and regularity of adverse drug reactions(ADRs)in Qinghai Provincial People’s Hospital in 2020 so as to provide reference for clinical safe drug usage.Methods:Through retrospective study,220 cases of ADRs reported in 2020 were selected to analyze and evaluate the characteristics and regularity.Results:In the 220 patients with ADRs,the male-female ratio was 1∶0.83,which mainly occurred in patients over 50 years old(72.72%),and mainly occurred in hospitalized patients with 40 to 50 years old(15.45%).The main drugs involved were anti-tumor drugs and antibacterial drugs(26.36% and 17.27%,respectively).The main clinical manifestations of ADRs were skin and accessory damage and digestive system damage(25.00% and 24.55%,respectively)and the dosage forms and delivery routes involved were injection(60.00%)and intravenous administration(54.55%).Conclusion:Clinical attention should be paid to the safe usage of anti-tumor drugs and intravenous antibacterials,and the publicity of rational drug usage knowledge should be strengthened so as to improve the level of rational drug usage.

关 键 词：药物不良反应 合理用药 抗菌药物 抗肿瘤药物 

分 类 号：R969.3[医药卫生—药理学]