果糖-1,6-二磷酸醛缩酶的研究进展  

Research Progress of Fructose-1,6-bisphosphate Aldolase

作　　者：肖舒文 胡永红[1] XIAO Shuwen;HU Yonghong(College of Life Sciences,Hebei Normal University,Hebei Shiiazhuang 050024,China)

机构地区：[1]河北师范大学生命科学学院,河北石家庄050024

出　　处：《河北师范大学学报（自然科学版）》2022年第3期297-303,共7页Journal of Hebei Normal University：Natural Science

基　　金：河北省自然科学基金(C2021205010);河北师范大学重点基金(L2020Z06)。

摘　　要：果糖-1,6-二磷酸醛缩酶(FBA)是糖酵解途径中一种重要的生物酶,可催化底物果糖-1,6-二磷酸裂解.为3-磷酸甘油醛和磷酸二羟丙酮或反向的醛醇缩合反应.主要介绍了FBA的分类及其功能,如参与生物体内代谢、充当纤溶酶原结合蛋白、作为宿主细胞粘附结合剂转录调节因子等,并总结了FBA在抗真菌药物靶点、抗病原体疫苗方面的应用,旨在为后续FBA的深入研究提供基础资料.Fructose-1,6-bisphosphate Aldolase(FBA)is an important biological enzyme in the glycol-ysis pathway.It catalyzes the cleavage of the substrate fructose-1,6-bisphosphate into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate or the reverse aldol condensation reaction.In this article,we mainly introduced the classification of FBA and its function,such as participation in the metabolism of or-ganisms,as a plasminogen binding protein,as a host cell adhesion binding agent,transcription regulator and so on.Moreover,the application of FBA in anti-fungal drug targets and anti-pathogen vaccines were also summarized.Therefore,this article aims to provide basic information for the in-depth research of FBA in the future.

关 键 词：果糖-1 6-二磷酸醛缩酶 分类 生理功能 药物靶点 候选疫苗 

分 类 号：Q95[生物学—动物学]