近红外荧光探针检测β-淀粉样蛋白的研究进展  

Research progress of near-infrared fluorescent probes for detectingβ-amyloid

作　　者：盖婷婷 高春红 陈哲 蒲永利 沈增瑞 唐科友 许静[1] GAI Ting-ting;GAO Chun-hong;CHEN Zhe;PU Yong-li;SHEN Zeng-rui;TANG Ke-you;XU Jing(School of Chemistry and Chemical Engineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250000,China)

机构地区：[1]齐鲁工业大学(山东省科学院)化学与化工学院,山东济南250353

出　　处：《齐鲁工业大学学报》2022年第2期34-38,共5页Journal of Qilu University of Technology

基　　金：山东省级创新训练项目(S201910431064)。

摘　　要：阿尔茨海默病(AD)是一种病理机制非常复杂的进行性神经衰退性疾病,又叫老年痴呆症。目前尚无有效的诊断和治疗方法,使很多国内外中老年人深受AD的困扰。在早期,研究者们在对AD患者预防和治疗的过程中发现,β-淀粉样蛋白(Aβ)斑块对于临床诊断和监测AD疾病的进展至关重要。近红外荧光探针技术具有选择性良好、灵敏度较高、实时成像、成本低以及能够避免生物组织自荧光干扰等优点。小分子近红外荧光探针的设计合成是目前的热点研究领域。我们简要概述了近红外荧光(near infrared fluorescence,NIRF)分子探针用于特异性检测β-淀粉样蛋白(Aβ)斑块的最新研究进展及应用。Alzheimer’s disease(AD) is a progressive neurodegenerative disease with a very complex pathological mechanism, also called Alzheimer’s disease.Currently, there is no effective diagnosis and treatment method, so many middle-aged and elderly people at home and abroad are deeply troubled by AD.In the early stage, researchers discovered during the prevention and treatment of AD patients that β-amyloid(Aβ) plaques are essential for clinical diagnosis and monitoring of the progression of AD disease.Near-infrared fluorescent probe technology has the advantages of good selectivity, high sensitivity, real-time imaging, low cost, and avoidance of autofluorescence interference from biological tissues.The design and synthesis of small molecule near-infrared fluorescent probes is currently a hot research field.In this article, the latest research progress and applications of near infrared fluorescence(NIRF) molecular probes are briefly summarized for the specific detection of β-amyloid(Aβ) plaques.

关 键 词：Β-淀粉样蛋白 阿尔茨海默病 近红外 探针 成像 

分 类 号：O621.3[理学—有机化学]