贵州天名精化学成分及抗菌活性研究  

Study on chemical constituents and antibacterial activity of Carpesium faberi

作　　者：陈洁 王丹 张雄 彭明友 徐冉 晏英 王颖 CHEN Jie;WANG Dan;ZHANG Xiong;PENG Ming-you;XU Ran;YAN Ying;WANG Ying(College of Pharmacy,Guizhou Medical University,Guiyang 550025,China;Engineering Technology Research Center for Chemical Drug R&D,Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学药学院,贵阳550025 [2]贵州医科大学贵州省化学合成药物研发利用工程技术研究中心,贵阳550004

出　　处：《天然产物研究与开发》2022年第4期598-605,共8页Natural Product Research and Development

基　　金：国家自然科学基金(31760089);贵州省自然科学基金项目资助项目(黔科合基础[2017]1141);贵阳市科技局计划项目(筑科合同[2017]30-28)。

摘　　要：为研究贵州天名精(Carpesium faberi)的化学成分和抗菌活性研究,应用多种色谱方法从天名精全草的乙醇提取物中分离得到14个单体化合物,并运用现代波谱技术其鉴定结构,分别为大叶土木香内酯(1)、4α,10α-二羟基-1βH,5βH-11(13)-烯-12,8α-愈创木酚(2)、4β,10β-二羟基-5α(H)-1,11(13)-二烯-8α,12-愈创木酚(3)、4-表异粘性旋覆花内酯(4)、11(13)-去氢腋生依瓦菊素(5)、天名精内酯酮(6)、吐叶醇(7)、cassipourol(8)、4′,5′-dehydrodiodictyonema A(9)、(3R)-8-羟基香叶醇(10)、胆甾-7-烯-3β-醇(11)、豆甾醇(12)、5,8-表双氧麦角甾-6,22-二烯-3β-醇(13)、豆甾-5,22-二烯-3β,7α-二醇(14)。其中化合物2和7~14为首次从该植物中得到。初步评估了化合物1~14的抗菌活性,化合物1对枯草芽孢杆菌表现出弱活性;化合物6和10对白色念珠菌显示出弱活性。In order to study the chemical composition and antibacterial activity of Carpesium faberi,14 compounds were obtained from the ethanol extract of C.faberi by applying various chromatographic techniques.Their structures were elucidated and identified as granilin(1),4α,10α-dihydroxy-1βH,5βH-guai-11(13)-en-12,8α-olide(2),4β,10β-dihydroxy-5α(H)-1,11(13)-guaidien-8α,12-olide(3),4-epi-isoinuviscolide(4),11(13)-dehydroivaxillin(5),carabrone(6),vomifoliol(7),cassipourol(8),4′,5′-dehydrodiodictyonema A(9),(3R)-8-Hydroxylinalool(10),cholest-7-en-3β-ol(11),stigmasterol(12),5,8-epidioxy-5α,8α-ergosta-6,22E-dien-3β-ol(13),stigmasta-5,22-diene-3β,7α-diol(14).Among them,compounds 2 and 7-14 were obtained from this plant for the first time.The antibacterial activity of compounds 1-14 was preliminarily evaluated,and compound 1 showed weak activity against Bacillus subtilis;compounds 6 and 10 showed weak activity against Candida albicans.

关 键 词：贵州天名精 化学成分 分离鉴定 抗菌活性 

分 类 号：R284.1[医药卫生—中药学] R932[医药卫生—中医学]