低氧诱导因子在急慢性肾脏病中的作用及相关药物治疗前景  

Effect of Hypoxic Inducible Factor in Acute and Chronic Kidney Diseases and Treatment Prospects of Related Drugs

作　　者：李煜 姚颖[1] LI Yu;YAO Ying(Department of Nephrology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院肾内科,武汉430030

出　　处：《医药导报》2022年第4期491-497,共7页Herald of Medicine

基　　金：国家自然科学基金面上项目(81770684,81974087)。

摘　　要：低氧是细胞或生物体氧气供应不足的一种状态,可发生于各个组织器官的微循环损伤或灌注不足。正常成人安静状态下肾血流量占心排血量的20%~25%,因此血流动力学的轻微改变容易导致肾脏缺氧。低氧诱导因子(HIF)是一种有助于细胞感知和适应氧变化的转录因子,在低氧状态下细胞和组织对低氧压力的适应导致HIF激活一系列基因的转录,这些基因参与了血管生成、铁代谢、葡萄糖代谢和细胞增殖与凋亡。新近证据表明HIF和缺氧反应在各种急性肾损伤(AKI)和慢性肾脏病(CKD)的发生发展中起着重要作用。该文就HIF的调节机制、相关靶基因在肾脏病中的作用及相关药物在肾脏病中的治疗前景等方面进行探讨。Hypoxia is a state of insufficient oxygen supply in cells or organisms.It can occur in the microcirculation damage or hypoperfusion of various tissues and organs.In normal adults,renal blood flow accounts for 20 to 25 percent of cardiac output in a normal calm state,so slight changes in hemodynamics can easily lead to renal hypoxia.Hypoxia-inducible factor(HIF)is a transcription factor that helps cells sense and adapts to changes in oxygen.Adaptation of cells and tissues to hypoxia stress under hypoxia conditions results in HIF activating a series of genes transcription.These genes are involved in angiogenesis,iron metabolism,glucose metabolism,and cell proliferation and apoptosis.Recent evidence suggests that HIF and hypoxia response play an important role in the development of various acute kidney injury(AKI)and chronic kidney disease(CKD).This article will discuss the regulatory mechanism of HIF,the role of related target genes in renal disease,and therapeutic prospects of related drugs in renal disease.

关 键 词：低氧诱导因子 急性肾损伤 损伤修复 纤维化 慢性肾脏病 

分 类 号：R97[医药卫生—药品]