尿毒症患者肺毛霉菌感染的药学监护  

Pharmaceutical Care for a Uremic Patient with Pulmonary Mucormycosis Infection

作　　者：阳霞 李冬艳 唐敏 YANG Xia;LI Dongyan;TANG Min(Department of Pharmacy,Fushun People's Hospital,Zigong City,Sichuan Province,Zigong 643200,China;Department of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Pharmacy,the First Affiliated Hospital of Army Medical University,Chongqing 400038,China)

机构地区：[1]四川省自贡市富顺县人民医院药剂科,自贡643200 [2]华中科技大学同济医学院附属同济医院药学部,武汉430030 [3]陆军军医大学第一附属医院药剂科,重庆400038

出　　处：《医药导报》2022年第4期563-566,共4页Herald of Medicine

摘　　要：目的探讨临床药师参与慢性肾衰竭患者肺毛霉菌感染治疗的药学实践。方法临床药师通过文献学习和药学工具检索,综合患者的经济条件、基础疾病、用药依从性、循证医学证据等,与临床医师共同制定局部使用两性霉素B的抗感染方案,监测药物不良反应。结果通过纤支镜下滴注两性霉素B较静脉治疗起效快,无复发,且节约经济成本。结论临床药师参与慢性肾衰竭并肺毛霉菌感染患者的治疗过程,实施全程药学监护,协助临床医师制定个体化治疗方案,进行有效干预和建议,提高治疗效果,减少了不良反应,减轻了患者经济负担。Objective To explore clinical pharmacists’participating in the treatment of pulmonary mucormycosis infection in patients with chronic renal failure.Methods Through literature study and pharmaceutical tool retrieval,clinical pharmacists took the patient’s economic condition,underlying diseases,medication compliance,evidence-based medicine,and other methods into consideration,and finally worked with clinicians to formulate anti-infective regimen for the use of topical amphotericin B and monitored adverse drug reactions.Results Infusion of amphotericin B under bronchoscopy had a faster onset than the intravenous therapy with no recurrence and economic cost savings.Conclusion Clinical pharmacists participated in the treatment process of patients with chronic renal failure and pulmonary mucormycosis infection,implemented full pharmaceutical monitoring,assisted clinicians in specifying individualized treatment plans,and provided effective interventions and recommendations to improve the cure rate and reduce adverse reactions and the patient’s medical economic burden.

关 键 词：毛霉菌 两性霉素B 肺部感染 临床药师 

分 类 号：R969.3[医药卫生—药理学] R969.4[医药卫生—药学]