HIV母婴阻断成功婴幼儿贫血状况及影响因素分析  

Investigation on anemia status and influencing factors in infants with successful mother-infant blocking of HIV

作　　者：胡丹[1] 朱炜春 HU Dan;ZHU Wei-chun(Department of Pediatrics,Guangzhou Eighth Hospital Affiliated to Guangzhou Medical University,Guangzhou 510060,Guangdong,CHINA)

机构地区：[1]广州医科大学附属市八医院儿科,广东广州510060

出　　处：《海南医学》2022年第8期1013-1015,共3页Hainan Medical Journal

摘　　要：目的调查人类免疫缺陷病毒(HIV)母婴阻断成功的6~18个月婴幼儿的血红蛋白(Hb)水平及贫血发生率,并分析贫血的影响因素。方法选择2017年1月至2019年9月期间在广州医科大学附属市八医院由HIV感染母亲分娩的134例非HIV感染婴幼儿作为观察组,另选择同期在本院由健康母亲分娩的134例婴幼儿作为对照组,比较两组婴幼儿6~18个月时的血红蛋白水平及贫血发生率。调查观察组婴幼儿母亲孕期时母亲贫血情况,以及胎数、胎龄、出生体质量及预防用药、喂养情况,对可能的影响因素进行Logistic回归分析。结果观察组婴幼儿血红蛋白水平为(117.76±23.67)g/L,明显低于对照组的(123.95±25.15)g/L,婴幼儿贫血的发生率为25.37%,明显高于对照组的14.18%,差异均有统计学意义(P<0.05);观察组中,贫血组婴幼儿在年龄(<12个月)、早产、出生体质量(<2.5 kg)、辅食添加(>6个月)、使用齐多夫定及母亲孕期贫血方面的比例明显高于非贫血组,差异均有统计学意义(P<0.05);Logistic回归分析显示,低出生体质量、母亲孕期贫血是HIV感染母亲分娩的非HIV感染婴幼儿贫血的独立危险因素(P<0.05)。结论6~18个月HIV母婴阻断成功婴幼儿贫血发生率较高,其中低出生体质量、母亲孕期贫血是婴幼儿贫血的独立危险因素。Objective To investigate the hemoglobin(HB)level and the incidence of anemia in 6 to 18-month-old infants with successful mother-infant blocking of HIV,and to analyze the influencing factors of anemia.Methods A total of 134 infants without HIV infection delivered by HIV-infected mothers in Department of Pediatrics,Guangzhou Eighth Hospital Affiliated to Guangzhou Medical University from January 2017 to September 2019 were selected as the research subjects(observation group),and 134 infants delivered by healthy mothers in the same period were selected as the control group.The hemoglobin level and anemia incidence rate at 6-18 months were compared between the two groups.The maternal anemia during pregnancy of pregnant woman,number of fetuses,gestational age,birth weight,prophylactic drugs,and feeding of children in the observation group were investigated,and the possible influencing factors were analyzed by Logistic regression.Results The hemoglobin level of the observation group was(117.76±23.67)g/L,significantly lower than(123.9±25.15)g/L in the control group;the incidence of anemia in the observation group was 25.37%,significantly higher than 14.18%in the control group;the differences were statistically significant(P<0.05).The proportions of age<12 months,premature birth,birth weight<2.5 kg,complementary food>6 months,zidovudine use,and maternal anemia in anemia group were significantly higher than those in non-anemia group(P<0.05).Logistic regression analysis showed that low birth weight and maternal anemia during pregnancy were independent risk factors for anemia in children without HIV infection delivered by HIV-infected mothers(P<0.05).Conclusion The incidence of anemia in 6 to 18-month old infants with successful mother-infant blocking of HIV of is high.Low birth weight and maternal anemia during pregnancy are independent risk factors for anemia in children.

关 键 词：人类免疫缺陷病毒 血红蛋白 贫血 低出生体质量 危险因素 

分 类 号：R725.5[医药卫生—儿科]