麻杏二三汤加减联合推拿治疗儿童慢性咳嗽痰湿阻肺证的疗效及对患儿肺功能、炎症因子水平的影响  

Clinical efficacy of modified Maxing Ersan Decoction combined with massage in the treatment of children's chronic cough with phlegm-dampness obstructive lung syndrome and its effect on lung function and inflammatory factor levels

作　　者：郭芬芳 武青 GUO Fen-fang;WU Qing(Department of Pediatrics,Shanghai Pudong New Area Hospital of Traditional Chinese Medicine,Shanghai 201299,CHINA)

机构地区：[1]上海市浦东新区中医医院儿科,上海201299

出　　处：《海南医学》2022年第8期1024-1026,共3页Hainan Medical Journal

摘　　要：目的探讨麻杏二三汤加减联合推拿治疗儿童慢性咳嗽痰湿阻肺证的疗效及对患儿肺功能、炎症因子水平的影响。方法选取2019年1月至2021年4月于上海市浦东新区中医医院治疗的156例儿童慢性咳嗽痰湿阻肺证患者为研究对象,依据随机数表法分为对照组与联合组,每组78例。对照组患儿采用推拿治疗,联合组患儿在对照组治疗的基础上采用麻杏二三汤加减治疗。治疗1个月后,比较两组患儿的临床疗效、第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、呼气高峰流量(PEFR)、最大通气量(MVV)、动脉血氧分压(PaO_(2))、白介素-4(IL-4)、免疫球蛋白E(IgE)和肿瘤坏死因子-α(TNF-α)水平。结果联合组患儿的治疗总有效率为93.59%,明显高于对照组的80.78%,差异有统计学意义(P<0.05);治疗后,联合组患儿的FEV_(1)、FVC、PEFR、MVV、PaO_(2)分别为(3.11±0.57)L、(3.99±0.59)L、(4.03±0.40)L/s、(2.16±0.39)L/min、(85.45±9.26)mmHg,明显高于对照组的(2.68±0.52)L、(3.16±0.50)L、(3.16±0.28)L/s、(1.41±0.29)L/min、(67.19±8.24)mmHg,差异均具有统计学意义(P<0.05);治疗前,两组患儿的IL-4、IgE、TNF-α水平比较差异均无统计学意义(P>0.05);治疗后,联合组患儿的IL-4、IgE、TNF-α水平分别为(15.82±4.20)pg/mL、(141.16±35.61)IU/mL、(51.37±18.33)pg/mL,明显低于对照组的(22.13±6.52)pg/mL、(180.74±50.23)IU/mL、(86.94±21.53)pg/mL,差异均有统计学意义(P<0.05)。结论麻杏二三汤加减联合推拿治疗儿童慢性咳嗽痰湿阻肺证可明显改善患儿肺功能及炎症因子水平,临床应用效果显著,值得推广应用。Objective To explore the curative effect of modified Maxing Ersan Decoction combined with massage in treating children's chronic cough with phlegm-dampness obstructive lung syndrome and its influence on lung function and levels of inflammatory factors.Methods A total of 156 children with chronic cough,phlegm,dampness and lung obstruction syndrome treated in Shanghai Pudong New Area Hospital of Traditional Chinese Medicine from January 2019 to April 2021 were selected as the research objects.The patients were divided into control group and combined group according to random number table method,with 78 patients in each group.Children in the control group were treated with massage,and children in the combined group were treated with modified Maxing Ersan decoction on the basis of treatment in the control group.After a month of treatment,the clinical efficacy,forced expiratory volume in the first second(FEV_(1)),forced vital capacity(FVC),peak expiratory flow rate(PEFR),maximal voluntary ventilation(MVV),arterial partial pressure of oxygen(PaO_(2)),interleukin-4(IL-4),immunoglobulin E(IgE),and tumor necrosis factor-α(TNF-α)levels were compared between the two groups.Results The total effective rate of combined group was 93.59%,which was significantly higher than 80.78%of the control group(P<0.05);after treatment,FEV_(1),FVC,PEFR,MVV,and PaO_(2)in the combined group were(3.11±0.57)L,(3.99±0.59)L,(4.03±0.40)L/s,(2.16±0.39)L/min,(85.45±9.26)mmHg,significantly higher than(2.68±0.52)L,(3.16±0.50)L,(3.16±0.28)L/s,(1.41±0.29)L/min,(67.19±8.24)mmHg in the control group(P<0.05).Before treatment,there were no significant differences in IL-4,IgE,and TNF-αlevels between the two groups(P>0.05);after treatment,IL-4,IgE,and TNF-αlevels in the combined group were(15.82±4.20)pg/mL,(141.16±35.61)IU/mL,and(51.37±18.33)pg/mL,which were significantly lower than(22.13±6.52)pg/mL,(180.74±50.23)IU/mL,(86.94±21.53)pg/mL in the control group(P<0.05).Conclusion Modified Maxing Ersan Decoction combined with massage has a sig

关 键 词：儿童慢性咳嗽 痰湿阻肺 麻杏二三汤 推拿 疗效 肺功能 白介素-4 免疫球蛋白E 肿瘤坏死因子-α 

分 类 号：R725.6[医药卫生—儿科]