支气管哮喘儿童IOS指标与PFT指标的变化及相关性分析  

Changes and correlation analysis of IOS index and pulmonary function test index in children with bronchial asthma

作　　者：何志炜[1] 罗汉球 陈振声 HE Zhi-wei;LUO Han-qiu;CHEN Zhen-sheng(First Department of Pediatrics,Dongguan People's Hospital,Dongguan 523000,Guangdong,CHINA)

机构地区：[1]东莞市人民医院儿科一区,广东东莞523000

出　　处：《海南医学》2022年第8期1046-1049,共4页Hainan Medical Journal

摘　　要：目的探讨支气管哮喘儿童脉冲振荡肺功能检查(IOS)指标与常规肺功能检查(PFT)指标的变化及其相关性。方法回顾性分析2020年1月至2021年3月东莞市人民医院收治的100例支气管哮喘患儿的临床资料,根据患儿病情不同分为急性发作期21例、慢性持续期54例和临床缓解期25例。比较三组患儿的IOS指标[呼吸总阻抗(Zrs)、呼吸道总阻力(R_(5))、中心呼吸道阻力(R_(20))、周边呼吸道阻力(R_(5)~R_(20))、周边弹性阻力(X_(5))、响应频率(Fres)]以及PFT指标[第一秒用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)、呼气峰值流量(PEF)、用力呼出25%、50%、75%肺活量时的瞬间呼气流量(PEF_(25)、PEF_(50)、PEF_(75))及最大呼气中期流量(MMEF)],并采用Pearson相关性分析法分析IOS指标和PFT指标的相关性。结果急性发作期患儿Zrs、R_(5)、R_(20)、R_(5)~R_(20)、X_(5)、Fres分别为(1.33±0.19)kPa/(L·s)、(126.82±20.51)%pred、(98.67±9.10)%pred、(198.75±25.17)%pred、(143.03±17.86)%pred、(18.76±2.10)Hz,明显高于慢性持续期患儿的(1.17±0.16)kPa/(L·s)、(84.19±15.66)%pred、(83.32±7.69)%pred、(109.24±16.53)%pred、(79.23±10.14)%pred、(12.05±1.73)Hz和临床缓解期患儿的(0.92±0.14)kPa/(L·s)、(72.53±10.74)%pred、(73.00±7.15)%pred、(85.81±10.62)%pred、(45.96±6.92)%pred、(8.42±1.61)Hz,且慢性持续期患儿上述指标均明显高于临床缓解期,差异均有统计学意义(P<0.05);急性发作期患儿FEV1、FEV1/FVC、PEF、PEF_(25)、PEF_(50)、PEF_(75)、MMEF分别为(1.28±0.13)L、(76.50±4.86)%、(2.40±0.36)L/s、(1.98±0.16)L/s、(1.05±0.14)L/s、(0.50±0.06)L/s、(0.96±0.08)L/s,明显低于慢性持续期患儿的(1.43±0.15)L、(85.61±6.77)%、(3.51±0.44)L/s、(2.57±0.26)L/s、(1.63±0.17)L/s、(0.78±0.10)L/s、(1.28±0.13)L/s和临床缓解期患儿的(1.57±0.16)L、(93.15±5.48)%、(4.60±0.53)L/s、(3.69±0.40)L/s、(2.50±0.23)L/s、(1.06±0.12)L/s、(1.52±0.18)L/s,且慢性持续期患儿上述指标Objective To investigate the changes and correlation between impulse oscillometry(IOS)index and routine pulmonary function test(PFT)index in children with bronchial asthma.Methods The clinical data of 100 children with bronchial asthma in Dongguan People's Hospital from January 2020 to March 2021 were retrospectively analyzed.According to their different conditions,the children were divided into 21 cases of acute attack stage,54 cases of chronic duration stage,and 25 cases of clinical remission stage.The IOS indexes[total impedance of respiration(Zrs),total respiratory resistance(R_(5)),central respiratory resistance(R_(20)),peripheral respiratory resistance(R_(5)~R_(20)),peripheral elastic resistance(X_(5)),response frequency(Fres)]and PFT indexes[the forced expiratory volume in the first second(FEV1),FEV1/forced vital capacity(FVC),peak expiratory flow(PEF),instantaneous expiratory flow at forced expiratory 25%,50%,75%vital capacity(PEF_(25),PEF_(50),PEF_(75)),and maximum mid expiratory flow(MMEF)]were compared among the three groups.Pearson correlation analysis was used to analyze the correlation between IOS index and PFT index.Results The Zrs,R_(5),R_(20),R_(5)~R_(20),X_(5),and Fres in the children of acute attack stage were(1.33±0.19)kPa/(L·s),(126.82±20.51)%pred,(98.67±9.10)%pred,(198.75±25.17)%pred,(143.03±17.86)%pred,(18.76±2.10)Hz,which were significantly higher than(1.17±0.16)kPa/(L·s),(84.19±15.66)%pred,(83.32±7.69)%pred,(109.24±16.53)%pred,(79.23±10.14)%pred,(12.05±1.73)Hz in children of chronic duration stage and(0.92±0.14)kPa/(L·s),(72.53±10.74)%pred,(73.00±7.15)%pred,(85.81±10.62)%pred,(45.96±6.92)%pred,(8.42±1.61)Hz in children of clinical remission stage,and the above indexes in children of chronic duration stage were significantly higher than those of children of clinical remission stage;the differences were statistically significant(P<0.05).FEV1,FEV1/FVC,PEF,PEF_(25),PEF_(50),PEF_(75),MMEF in children of acute attack stage were(1.28±0.13)L,(76.50±4.86)%,(2.40±0.36)L/s,(1

关 键 词：儿童 支气管哮喘 脉冲振荡肺功能检查 常规肺功能检查 相关性 

分 类 号：R725.6[医药卫生—儿科]