HLA-G与母胎免疫耐受及妊娠期相关疾病的研究进展  

Research progress of HLA-G and maternal-fetal immune tolerance and pregnancy-related diseases

作　　者：张媛媛(综述) 张若鹏(审校) ZHANG Yuan-yuan;ZHANG Ruo-peng(Clinical Medical College,Dali University,Dali 671000,Yunnan,CHINA;Department of Reproductive Medicine,the First Affiliated Hospital of Dali University,Dali 671000,Yunnan,CHINA;Institute of Reproductive Medicine,Dali University,Dali 671000,Yunnan,CHINA)

机构地区：[1]大理大学临床医学院,云南大理671000 [2]大理大学第一附属医院生殖医学科,云南大理671000 [3]大理大学生殖医学研究所,云南大理671000

出　　处：《海南医学》2022年第8期1054-1057,共4页Hainan Medical Journal

基　　金：国家自然科学基金(编号:81860271);云南省医学学科带头人培养对象(编号:D-2017020);云南省“万人计划”名医专硕人才(编号:云卫人发【2019】35号);大理大学第八批中青年学术带头人后备人才(编号:理大研发【2017】2号);大理大学生殖医学创新团队(编号:ZKLX2019320)。

摘　　要：妊娠是一种既复杂又精细的特殊生理现象,可以认为是同种异体移植,胎儿虽携带有遗传自父系的人类白细胞抗原(HLA),但母体免疫系统对表达异体抗原的胎儿既不排斥,也不攻击。这一现象与母胎界面特异性免疫耐受有关。而HLA-G被认为是母胎免疫耐受产生和维持的关键,是母胎免疫耐受调节中的主导因素。目前,HLA-G已经受到越来越多的关注,大量研究表明,许多妊娠期相关疾病的产生同时伴随着HLA-G的异常表达。本文对HLA-G在母胎界面免疫耐受及妊娠期相关疾病的研究进展做一综述。Pregnancy is a complex and delicate special physiological phenomenon that can be thought of as an allograft.The fetus carries human leukocyte antigen(HLA)inherited from the paternal line,but the maternal immune system does not reject or attack the fetus expressing the allogeneic antigen.This phenomenon is related to the specific immune tolerance of maternal-fetal interface.HLA-G is considered to be the key to the generation and maintenance of maternal-fetal immune tolerance and is the dominant factor in the regulation of maternal-fetal immune tolerance.At present,HLA-G has attracted more and more attention.A large number of studies have shown that many pregnancy-related diseases are accompanied by abnormal expression of HLA-G.This paper reviews the research progress of HLA-G immune tolerance at the mother-fetal interface and related diseases during pregnancy.

关 键 词：人类白细胞抗原-G 妊娠 免疫 耐受 妊娠期相关疾病 

分 类 号：R714.2[医药卫生—妇产科学]