Ambulatory diastolic blood pressure:a marker of comorbidity in elderly fit hypertensive individuals?  

作　　者：Alfredo De Giorgi Rosaria Cappadona Caterina Savriè Benedetta Boari Ruana Tiseo Giulia Marta Viglione Christian Molino Elisa Misurati Mauro Pasin Roberto Manfredini Fabio Fabbian 

机构地区：[1]Clinica Medica Unit,Azienda Ospedaliero-Universitaria S.Anna,Ferrara,Italy [2]Department of Medical Sciences,University of Ferrara,Ferrara,Italy

出　　处：《Journal of Geriatric Cardiology》2022年第4期254-264,共11页老年心脏病学杂志（英文版）

摘　　要：BACKGROUND Masked diastolic hypotension is a new blood pressure(BP)pattern detected by ambulatory blood pressure monitoring(ABPM)in elderly hypertensives.The aim of this study was to relate ABPM and comorbidity in a cohort of fit elderly subjects attending an outpatient hypertension clinic.METHODS Comorbidity was assessed by Charlson comorbidity index(CCI)and CHA_(2)DS_(2)VASc score.All subjects evaluated with ABPM were aged≥65 years.CCI and CHA_(2)DS_(2)VASc score were calculated.Diastolic hypotension was defined as mean am-bulatory diastolic BP<65 mmHg and logistic regression analysis was carried out in order to detect and independent relationship between comorbidity burden and night-time diastolic BP<65 mmHg.RESULTS We studied 174 hypertensive elderly patients aged 72.1±5.2 years,men were 93(53.4%).Mean CCI was 0.91±1.14 and mean CHA_(2)DS_(2)VASc score of 2.68±1.22.Subjects with night-time mean diastolic values<65 mmHg were higher in females[54.7%vs.45.3%,P=0.048;odds ratio(OR)=1.914,95%CI:1.047−3.500].Logistic regression analysis showed that only CHA_(2)DS_(2)-VASc score was independently associated with night-time mean diastolic values<65 mmHg(OR=1.518,95%CI:1.161−1.985;P=0.002),but CCI was not.CONCLUSIONS ABPM and comorbidity evaluation appear associated in elderly fit subjects with masked hypotension.Com-orbid women appear to have higher risk for low ambulatory BP.

关 键 词：HYPERTENSIVE MORBIDITY DIASTOLIC 

分 类 号：R544.1[医药卫生—心血管疾病]