果糖脱水制备5-羟甲基糠醛及分离纯化  

Production and purification of 5-hydroxymethylfurfural from fructose dehydration

作　　者：刘迎新[1] 李愈 方鑫 姚恩 魏作君[2,3] LIU Ying-xin;LI Yu;FANG Xin;YAO En;WEI Zuo-jun(College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310014,China;Key Laboratory of Biomass Chemical Engineering of the Ministry of Education,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China;Institute of Zhejiang University-Quzhou,Quzhou 324000,China)

机构地区：[1]浙江工业大学药学院,浙江杭州310014 [2]浙江大学生物质化工教育部重点实验室,浙江大学化学工程与生物工程学院,浙江杭州310027 [3]浙江大学衢州研究院,浙江衢州324000

出　　处：《高校化学工程学报》2022年第2期211-217,共7页Journal of Chemical Engineering of Chinese Universities

基　　金：国家自然科学基金(21878269,21476211);浙江省自然科学基金(LY18B060016)。

摘　　要：为了解决果糖酸催化脱水制备5-羟甲基糠醛(5-HMF)及分离纯化过程中存在的低收率、低纯度等问题,提出低沸点溶剂中酸催化高浓度果糖生产5-HMF的方法,在此基础上,通过添加亚硫酸氢钠的饱和氯化钠溶液将反应液中5-HMF转化为易溶于水的磺酸钠盐,实现5-HMF与胡敏素等杂质的有效分离。结果表明,在四氢呋喃溶剂中,质量分数为24%的果糖在140℃下反应30 min,5-HMF最高收率达83.8%;采用亚硫酸氢钠分离工艺可得到工艺总收率为82.8%、纯度为95.1%的5-HMF。5-Hydroxymethylfurfural(5-HMF)is a versatile biomass platform molecule which plays essential roles in fine chemicals.In order to solve the problems of low yield and low purity in 5-HMF preparation and separation via acid-catalyzed dehydration of fructose,acid-catalyzed dehydration of high-concentration fructose in low-boiling-point solvent was proposed.In addition,effective separation and purification of 5-HMF from impurities such as humins was achieved through converting 5-HMF into water-soluble sodium sulfonate by adding sodium bisulfite contained saturated sodium chloride solution.The results show that the highest yield of 5-HMF was 83.8%when 24%of fructose was dehydrated at 140℃for 30 min in tetrahydrofuran solvent,and the total yield of 5-HMF was 82.8%with purity of 95.1%by sodium bisulfite separation.

关 键 词：果糖 5-羟甲基糠醛 胡敏素 亚硫酸氢钠 分离 

分 类 号：O622.3[理学—有机化学]