硫化铋@铁酸铜异质结的构筑及光触发抗菌性能研究  

Construction of Bi_(2)S_(3)@CuFe_(2)O_(4) heterojunction for photo-activated antibacterial application

作　　者：韩秋阳 于照晗 何帅 杨为中[2] 谢克难[1] 谢璐 邓怡[1] HAN Qiuyang;YU Zhaohan;HE Shuai;YANG Weizhong;XIE Kenan;XIE Lu;DENG Yi(School of Chemical Engineering, Sichuan University, Chengdu 610065, China;College of Biomedical Engineering, Sichuan University, Chengdu 610065, China;West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)

机构地区：[1]四川大学化学工程学院,成都610065 [2]四川大学生物医学工程学院,成都610065 [3]四川大学华西口腔医院,成都610041

出　　处：《功能材料》2022年第4期4020-4027,共8页Journal of Functional Materials

基　　金：国家自然科学基金委员会与香港研究资助局联合科研资助基金项目(81961160736);国家自然科学基金委员会青年科学基金项目(81801848,52002255)。

摘　　要：病原体细菌感染引起的相关感染在世界范围内严重威胁着人类的生命安全健康。为解决该问题,研究构筑了一种由硫化铋(Bi_(2)S_(3))与铁酸铜(CuFe_(2)O_(4))共筑形成的近红外光触发的异质结功能材料体系Bi_(2)S_(3)@CuFe_(2)O_(4),其通过Bi_(2)S_(3)与CuFe_(2)O_(4)之间的静电吸附作用力相结合。使用近红外光成像仪记录了材料在不同的近红外光功率下的升温曲线,验证了材料的光热效应;以1,3-二苯基异苯并呋喃(DPBF)作为活性氧的捕获剂,验证了材料的光动力效应。结果表明,Bi_(2)S_(3)@CuFe_(2)O_(4)在近红外光的触发下能够有效地产生热量,单线态氧(^(1)O_(2))与超氧根自由基(·O^(-)_(2))。抗菌实验以革兰氏阴性大肠杆菌(E.coli)及革兰氏阳性金黄色葡萄球菌(S.aureus)作为模型菌,验证了该种材料体系在近红外光触发下的广谱抗菌能力。结果表明,在近红外光的触发下该种材料体系针对S.aureus和E.coli两种不同类别的细菌均具有良好的抗菌能力。研究为消灭细菌提供了一种新的思路,同时为拓展新型异质结功能材料的应用了奠定实验基础。Pathogenic bacteria-induced infections threaten human safety and health throughout the whole world.To address this issue,we devise a novel NIR-triggered heterojunction materials(Bi_(2)S_(3)@CuFe_(2)O_(4))consisting of Bi_(2)S_(3) and CuFe_(2)O_(4) via the electrostatic interaction for the purpose of bactericidal therapy.The photothermal effect of materials is detected by using a thermal infrared camera under 808 nm NIR laser irradiation.The photodynamic effect of materials is assessed by 1,3-diphenylisobenzofuran(DPBF).The results show that Bi_(2)S_(3)@CuFe_(2)O_(4) can yield heat,^(1)O_(2) and·O^(-)_(2) effectively upon NIR illumination.Then,we employed Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli),representatives of Gram-positive and Gram-negative bacteria,respectively,to assess the bactericidal capacity of Bi_(2)S_(3)@CuFe_(2)O_(4).The results show that Bi_(2)S_(3)@CuFe_(2)O_(4) possess excellent antibacterial ability towards S.aureus and E.coli under NIR irradiation.Consequently,this research provides a novel method for the purpose of elimination of bacteria,and lays an experimental foundation for expanding the application of new heterojunction functional materials.

关 键 词：异质结功能材料 近红外光 光热/光动力效应 抗菌治疗 

分 类 号：TB34[一般工业技术—材料科学与工程]