复发性单纯疱疹感染抑制性治疗的临床疗效和患者生活质量改变研究  

Long-term inhibition treatment of recurrent herpes simplex infection in patients with clinical and quality of life

作　　者：高广程[1] 程海艳[1] 孙欣[2] 陈葵[3] 禚风麟[1] GAO Guang-cheng;CHENG Hai-yan;SUN Xin(Department of Dermatology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Dermatology,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京友谊医院皮肤性病科,北京100050 [2]首都医科大学附属北京佑安医院皮肤性病科,北京100069 [3]首都医科大学附属北京友谊医院神经内科,北京100050

出　　处：《临床和实验医学杂志》2022年第6期608-612,共5页Journal of Clinical and Experimental Medicine

基　　金：病原微生物生物安全国家重点实验室开放基金(编号:SKLPBS1830)。

摘　　要：目的探讨复发性单纯疱疹感染抑制性治疗的临床疗效和治疗前后患者生活质量的改变。方法前瞻性选取2018年4月至2020年12月首都医科大学附属北京友谊医院皮肤科门诊治疗的复发性生殖器疱疹患者120例,按入组时间随机分为A、B、C组,每组各40例。A组口服盐酸伐昔洛韦,B组在A组上再加皮下注射胸腺五肽,C组在A组上再给胸腺肽和白细胞介素-2局部病变部位皮下注射治疗。治疗4个月,停药6个月后随访平均复发次数,评定疗效;使用症状自评量表(SCL-90)和汉密尔顿抑郁量表(HAMD)评估治疗前后生活质量改变等实验数据。结果A组有效率为30.00%,B组有效率为55.00%,C组有效率为87.50%,C组的有效率更高,显著高于A组、B组,差异有统计学意义(P<0.05)。治疗前,3组的SCL-90加权总分、HAMD总分比较,差异无统计学意义(P<0.05);治疗结束后6个月,3组SCL-90加权平均总分、HAMD总分较治疗前显著降低,C组显著低于A组、B组,差异均有统计学意义(P<0.05)。结论3种抑制治疗均能获得理想的治疗效果,改善患者的临床症状,减少复发频率,提高生活质量,伐昔洛韦与胸腺肽+白介素联用治疗复发性单纯疱疹感染的效果最好,可在有条件的医院临床实践中推广应用。Objective To evaluate the effectiveness and the alteration of life quality with three different long-term inhibition therapy for recurrent genital herpes simplex.Methods A total of 120 patients with recurrent genital herpes who were treated in the Department of Dermatology Outpatient,Beijing Friendship Hospital,Capital Medical University,from April 2018 to December 2020 were prospectively selected and randomly divided into groups A,B,and C according to the time of enrollment,with 40 cases in each group.Group A was given oral valacyclovir hydrochloride,group B was given subcutaneous injection of thymopentin,and group C was given subcutaneous injection of thymosin and interleukin-2 to local lesions.The relapse times since the treatment after 4 months and 6 months after the last treatment and symptom checklist90(SCL-90),Hamilton depression scale(HAMD)rating scales were recorded.Results The effective rate of group A was 30.00%,the effective rate of group B was 55.00%,and the effective rate of group C was 87.50%.The effective rate of group C was higher,which was significantly higher than that of group A and group B,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the SCL-90 weighted total score and HAMD total score among the three groups(P<0.05);six months after the end of treatment,the weighted average total score of SCL-90 and HAMD total score in three groups were significantly lower than those before treatment,and group C was significantly lower than group A and group B,the differences were statistically significant(P<0.05).Conclusion All the treatments with group A/B/C were effective in reducing the relapse times,attenuating the symptoms and improving life quality.Among them,the most effective treatments were the combination of giving oral valaciclovir hydrochloride tablets,intramuscular injection of thymopentin and subcutaneous injection of IL-2 around the lesion at the same time.And this method could be applied and popularized in clinical practice.

关 键 词：复发性生殖器疱疹 免疫治疗 长期抑制疗法 生活质量 症状自评量表 汉密尔顿抑郁量表 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]