PJS、MRD参数与CTX-Ⅱ、COMP的相关性及对膝骨性关节炎的诊断价值  

Correlation between PJS and MRD parameters and CTX-Ⅱ and COMP and their diagnostic value for knee osteoarthritis

作　　者：颜林淋[1] 陈鹏[1] 李丛辉[1] YAN Lin-lin;CHEN Peng;LI Cong-hui(Department of Ultrasound,Affiliated Hospital(Clinical College)of Xiangnan University,Chenzhou Hunan 423000,China)

机构地区：[1]湘南学院附属医院(临床学院)超声科,湖南郴州423000

出　　处：《临床和实验医学杂志》2022年第6期632-636,共5页Journal of Clinical and Experimental Medicine

基　　金：湖南省郴州市科技局计划项目(编号:ZDYF2020183);湖南省科技计划项目(编号:2017SK4010)。

摘　　要：目的探究内侧外缘关节间隙(PJS)、内侧半月板突出值(MRD)与Ⅱ型胶原羟基端交联肽(CTX-Ⅱ)、软骨寡聚基质蛋白(COMP)的相关性及对膝骨性关节炎的诊断价值。方法前瞻性研究2020年3月至2021年4月湘南学院附属医院收治的疑似膝骨性关节炎患者196例,以手术确诊为金标准,确诊为96例膝骨性关节炎患者为研究组,其余100例健康人为对照组。使用GE Logiq E9彩色多普勒超声诊断仪检测PJS、MRD参数,对比两组PJS、MRD参数,ELISA测定CTX-Ⅱ、COMP水平,分析PJS、MRD参数与CTX-Ⅱ、COMP、严重程度水平的相关性,分析PJS、MRD参数对膝骨性关节炎的诊断价值。结果研究组PJS参数为(4.35±1.61)mm,显著低于对照组[(6.42±0.72)mm],MRD参数、CTX-Ⅱ、COMP水平为(5.24±1.37)mm、(291.42±13.26)ng/m L、(4.86±0.32)μg/L,均显著高于对照组[(2.33±0.55)mm、(153.84±9.48)ng/m L、(2.10±0.09)μg/L],差异均有统计学意义(P<0.05)。重度患者PJS参数低于中度和轻度,MRD参数、CTX-Ⅱ、COMP水平高于中度和轻度患者;中度患者PJS参数表达低于轻度,MRD参数、CTX-Ⅱ、COMP水平高于轻度患者,差异均有统计学意义(P<0.05)。PJS参数与CTX-Ⅱ、COMP、病情严重程度负相关(P<0.05),MRD参数与CTX-Ⅱ、COMP、病情严重程度正相关(P<0.05)。与PJS、MRD参数单项诊断相比,联合检测对膝骨性关节炎的诊断价值较高(P<0.05)。结论在膝骨性关节炎患者中CTX-Ⅱ、COMP水平较高,通过超声测量PJS、MRD参数可用于膝骨性关节炎的诊断,PJS、MRD参数与CTX-Ⅱ、COMP具有一定相关性,可评估患者疾病进展程度。Objective To explore the correlation between the peripheral joint space(PJS),the medial radial displacement of the medial meniscus(MRD)and the type collagen hydroxyterminal cross-linked peptide(C-terminal crosslinking telopeptide of typeⅡcollagen,CTX-Ⅱ),the cartilage oligo-mer matrix protein(cartilage oligomeric matrix protein,COMP),and the diagnostic value for knee osteoarthritis.Methods The prospective study included 196 patients with suspected knee osteoarthritis admitted to Xiangnan University Affiliated Hospital from March 2020 to April 2021,with the gold standard of 96 patients with confirmed knee osteoarthritis as the study group,and the remaining 100 healthy patients were in the control group.PJS and MRD parameters were detected using a GE Logiq E9 color Doppler ultrasound diagnostic instrument,comparing two groups of PJS and MRD parameters,CTX-Ⅱand COMP levels were determined by ELISA,the correlation between PJS and MRD parameters and CTX-Ⅱ,COMP,severity levels,and PJS,M The diagnostic value of RD parameters for knee osteoarthritis.Results The PJS parameter of the study group was(4.35±1.61)mm,which was significantly lower than that of the control group[(6.42±0.72)mm],and the levels of MRD parameters,CTX-Ⅱ,and COMP were(5.24±1.37)mm,(291.42±13.26)ng/mL,(4.86±0.32)μg/L,which were significantly higher than those of the control group[(2.33±0.55)mm,(153.84±9.48)ng/mL,(2.10±0.09)μg/L],the differences were statistically significant(P<0.05).In severe patients,PJS parameters were lower than moderate and mild,the levels of MRD parameters,CTX-Ⅱand COMP were higher than moderate and mild;moderate PJS parameters were lower than mild,and MRD parameters,CTX-Ⅱand COMP levels were higher than mild,the differences were statistically significant(P<0.05).PJS parameters and levels were negatively correlated with CTX-Ⅱ,COMP,and disease severity(P<0.05),and MRD parameters were negatively associated with CTX-Ⅱ,and C OMP and severity were positively related(P<0.05).Compared with the single diagnosis,P

关 键 词：膝骨性关节炎 内侧外缘关节间隙 内侧半月板突出值 Ⅱ型胶原羟基端交联肽 软骨寡聚基质蛋白 

分 类 号：R684.3[医药卫生—骨科学]