血清Hcy、IMA、Vaspin水平在原发性高血压患者并发急性脑梗死预测中的应用价值  

Application Value of Serum Hcy, IMA and Vaspin Levels in Predicting Acute Cerebral Infarction in Patients with Essential Hypertension

作　　者：陈世豪[1] 毛录祥 屈振汉 黄伟东[1] 谭晓晖[1] 赵子贤[1] CHEN Shihao;MAO Luxiang;QU Zhenhan;HUANG Weidong;TAN Xiaohui;ZHAO Zixian(Xinhui District People’s Hospital of Jiangmen City,Guangdong Province,Jiangmen 529100,China;不详)

机构地区：[1]广东省江门市新会区人民医院,广东江门529100

出　　处：《中国医学创新》2022年第11期165-168,共4页Medical Innovation of China

基　　金：广东省医学科学技术研究基金(C2020106)。

摘　　要：目的:探究血清同型半胱氨酸(Hcy)、缺血性修饰白蛋白(IMA)、内脏脂肪组织丝氨酸蛋白酶抑制因子(Vaspin)水平在原发性高血压(EH)患者并发急性脑梗死(ACI)预测中的应用价值。方法:回顾性分析2020年7-12月江门市新会区人民医院收治的120例EH患者临床资料,根据回访时间内是否并发ACI分为并发组(n=54)与单纯组(n=66),比较两组入院时Hcy、IMA、Vaspin水平,采用受试者工作特征曲线(ROC)分析各指标预测EH患者并发ACI价值;将并发组患者根据神经功能缺损程度分为A组(轻度组)、B组(中度组)、C组(重度组),比较三组患者的指标水平,分析各指标与神经功能缺损程度的相关性。结果:并发组Hcy、IMA水平均高于单纯组,Vaspin水平低于单纯组,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,联合预测的AUC大于Hcy、IMA、Vaspin单独预测的AUC(P<0.05)。三组Hcy、IMA水平比较,差异均有统计学意义(P<0.05)。C组、B组的Hcy、IMA水平均高于A组,且C组均高于B组,差异均有统计学意义(P<0.05)。三组Vaspin水平比较,差异无统计学意义(P>0.05)。Hcy、IMA水平与EH并发ACI患者的神经功能缺损程度呈正相关(r;=0.535、0.546,P<0.001);Vaspin水平与神经功能缺损程度无明显相关性(P>0.05)。结论:Hcy和IMA在EH患者并发ACI患者中呈高表达,且Hcy、IMA水平与EH并发ACI患者的神经功能缺损程度呈正相关。Objective:To explore the application value of serum homocysteine (Hcy),ischemia-modified albumin (IMA) and visceral adipose tissue-derived serine protease inhibitor (Vaspin) levels in predicting acute cerebral infarction (ACI) in patients with essential hypertension (EH).Method:The clinical data of 120 EH patients admitted to Xinhui District People’s Hospital of Jiangmen City from July to December 2020 were retrospectively analyzed.According to whether they had ACI or not,they were divided into the concurrent group (n=54) and the simple group (n=66).Hcy,IMA and Vaspin levels of the two groups were compared.The value of all indexes predicting ACI in EH patients was analyzed by receiver operating characteristic curve (ROC);the concurrent group of patients were divided into group A (mild group),group B (moderate group) and group C (severe group) according to the degree of neurological impairment.The index levels of patients in the three groups were compared and the correlation between each index and the degree of neurological impairment was analyzed.Result:The levels of Hcy and IMA in the concurrent group were higher than those in the simple group,while the level of Vaspin in the concurrent group was lower than that in the simple group,the differences were statistically significant (P<0.05).ROC curve analysis showed that the AUC predicted by Hcy,IMA and Vaspin was greater than those predicted by Hcy,IMA and Vaspin alone (P<0.05).There were statistically significant differences in Hcy and IMA levels among three groups (P<0.05).Hcy and IMA levels in the group C and group B were higher than those in the group A,and those in the group C were higher than those the in group B,the differences were statistically significant (P<0.05).There was no significant difference in Vaspin level among three groups (P>0.05).Hcy and IMA levels were positively correlated with the degree of neurological impairment in EH patients combined with ACI (r;=0.535,0.546,P<0.001).There was no significant correlation between Vaspin level and the d

关 键 词：原发性高血压 急性脑梗死 同型半胱氨酸 缺血性修饰白蛋白 

分 类 号：R544.11[医药卫生—心血管疾病] R743.33[医药卫生—内科学]