更昔洛韦在水痘患儿中的应用效果及对外周血T淋巴细胞亚群的影响研究  

Study on Application Effect of Ganciclovir in Children with Varicella and Its Influence on Peripheral Blood T Lymphocyte Subsets

作　　者：叶敏贞[1] YE Minzhen(Sanming Integrated Medicine Hospital,Fujian Province,Sanming 365000,China)

机构地区：[1]福建省三明市中西医结合医院,福建三明365000

出　　处：《中国医学创新》2022年第9期14-17,共4页Medical Innovation of China

摘　　要：目的:探究更昔洛韦在水痘患儿中的临床疗效及对外周血T淋巴细胞亚群的影响。方法:选取2017年6月-2020年1月三明市中西医结合医院收治的86例水痘患儿作为研究对象,将其依据随机数字表法分为阿昔洛韦组(对照组)和更昔洛韦组(观察组),每组43例。比较两组总有效率、不良反应发生率、症状体征改善时间、治疗前后感染相关指标(IL-1β、IL-6及IL-10)及外周血T淋巴细胞亚群(CD4^(+)及CD8^(+))。结果:观察组治疗5、7 d临床总有效率显著高于对照组,不良反应发生率显著低于对照组,症状体征改善时间短于对照组,差异均有统计学意义(P<0.05)。两组治疗前感染相关指标、外周血T淋巴细胞亚群比较,差异均无统计学意义(P>0.05);观察组治疗3、5、7 d感染相关指标、外周血T淋巴细胞亚群均显著优于对照组,差异均有统计学意义(P<0.05)。结论:更昔洛韦在水痘患儿中的临床疗效较好,且对外周血T淋巴细胞亚群的影响更为积极,因此在水痘患儿中的应用价值较高。Objective:To investigate the clinical effect of Ganciclovir in the treatment of children with varicella and its influence on peripheral blood T lymphocyte subsets.Method:A total of 86 children with varicella treated in Sanming Integrated Medicine Hospital from June 2017 to January 2020 were chosen as the study object,and they were randomly divided into Acyclovir group (the control group) and Ganciclovir group (the observation group) according to the method of random number table,43 cases in each group.Then the total effective rates,adverse reactions rates,improvement time of symptoms and signs,infection related indexes (IL-1β,IL-6 and IL-10) and peripheral blood T lymphocyte subsets (CD4^(+)and CD8^(+)) before and after treatment of two groups were compared.Result:The total effective rates of the observation group at 5,7 d of treatment were significantly higher than those of the control group,the adverse reactions rate was significantly lower than that of the control group,the improvement times of symptoms and signs were significantly shorter than those of the control group,there were statistically significant differences (P<0.05).The infection related indexes and peripheral blood T lymphocyte subsets of two groups before treatment were compared,there were no statistically significant differences (P>0.05);the infection related indexes and peripheral blood T lymphocyte subsets of the observation group at 3,5 and 7 d of treatment were significantly better than those of the control group,there were statistically significant differences (P<0.05).Conclusion:The clinical effect of Ganciclovir in the treatment of children with varicella is better,and its influence on peripheral blood T lymphocyte subsets are more obvious,so its application value in the children with varicella is higher.

关 键 词：更昔洛韦 水痘 小儿 外周血T淋巴细胞亚群 

分 类 号：R725.1[医药卫生—儿科]