1-肉桂酰基吡咯烷-2.5-二酮类物质的制备及应用  

Synthesis and Application of 1-Cinnamoylpyrrolidine-2,5-Diones

作　　者：李江红[1] 石克金[1] 张滢 贾东豪 陈林[1] Li Jianghong;Shi Kejin;Zhang Ying;Jia Donghao;Chen Lin(Sichuan Industrial Institute of Antibiotics,School of Pharmacy,Chengdu University,Chengdu 610106,Sichuan,China;School of Clinical Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan,China)

机构地区：[1]成都大学药学院四川抗菌素工业研究所,四川成都610106 [2]成都中医药大学临床医学院,四川成都611137

出　　处：《四川化工》2022年第2期1-3,共3页Sichuan Chemical Industry

摘　　要：用氢氧化钠将丁二酰亚胺制备成其钠盐,接着与肉桂酰氯反应,制备得到1-肉桂酰基吡咯烷-2.5-二酮,收率80%。苯基取代的1-肉桂酰基吡咯烷-2.5-二酮也能以优秀的收率得到。以1-肉桂酰基吡咯烷-2.5-二酮类为底物,高收率制备得到了咔啉酮和吡唑并δ-内酯。Succinimide was transformed its sodium salt with sodium hydroxide, and then reacted with cinnamoyl chloride to deliver 1-cinnamoylpyrrolidine-2.5-dione with a yield of 80%. Substituted 1-cinnamoylpyrrolidine-2.5-diones were also obtained in excellent yields. Applying 1-cinnamoylpyrrolidine-2.5-diones as substrates, carbolinone and pyrazole-fused δ-lactone were successfully prepared in high yields, respectively.

关 键 词：1-肉桂酰基吡咯烷-2.5-二酮 制备 应用 

分 类 号：O626.13[理学—有机化学]