马来酸左旋氨氯地平分散片和苯磺酸氨氯地平片治疗高血压伴发心绞痛患者的疗效  

Efficacy of L-Amlodipine Maleate Tablets and Amlodipine Besylate Tablets in the treatment of hypertension with angina pectoris

作　　者：兰谋 马丹娜 尹娟 李萍[3] 冯平[1] 彭源源 LAN Mou;MA Danna;YIN Juan;LI Ping;FENG Ping;PENG Yuanyuan(No.2 Department of Cardiology,Chongqing Beibei Hospital of Traditional Chinese Medicine,Chongqing 400700,China;Department of Anesthesiology,the 983 Hospital of Joint Logistic Support Force of PLA,Tianjin 300143,China;No.1 Department of Cardiology,Chongqing Beibei Hospital of Traditional Chinese Medicine,Chongqing 400700,China)

机构地区：[1]重庆市北碚区中医院心血管二科,重庆400700 [2]天津市联勤保障部队第983医院麻醉科,天津300143 [3]重庆市北碚区中医院心血管一科,重庆400700

出　　处：《西北药学杂志》2022年第2期105-110,共6页Northwest Pharmaceutical Journal

基　　金：国家科技重大专项课题(编号:2012ZX09101101)。

摘　　要：目的研究马来酸左旋氨氯地平分散片(玄宁)和苯磺酸氨氯地平片(络活喜)治疗高血压伴发心绞痛患者的临床疗效。方法选取重庆市北碚区中医院接收并采用玄宁治疗的冠心病心绞痛(AP)患者642例,并从同期接收并采用络活喜治疗的AP患者中选取642例。按照用药方式分为2组,分别为玄宁组及络活喜组,观察2组患者的临床疗效。结果玄宁组31例患者因自身原因在中途退出研究;2组患者治疗后血压均明显低于治疗前,玄宁组患者降压效果明显高于络活喜组,玄宁组患者心绞痛改善效果明显高于络活喜组;玄宁组患者不良反应发生率明显低于络活喜组,P<0.05;多因素回归分析玄宁(OR=0.550,95%CI:0.339~0.894)、基线舒张压(DBP)(OR=0.979,95%CI:0.959~0.999)是降低不良反应发生率的保护因素,脑血管病(OR=2.651,95%CI:1.651~4.258)是不良反应升高的危险因素。结论高血压合并心绞痛患者应用玄宁治疗产生的降压效果以及抗心绞痛效果比络活喜更好,可有效降低不良反应发生风险,且具有长效、安全和方便的优势,值得推广使用。Objective To study the clinical efficacy of L-Amlodipine Maleate Tablets(Xuanning)and Amlodipine Besylate Tablets(Luohuoxi)in the treatment of hypertensive patients with angina pectoris.Methods A total of 642 patients with coronary heart disease angina pectoris who were treated with Xuanning in Beibei Hospital of Traditional Chinese Medicine in Chongqing and 642 patients with coronary heart disease angina pectoris who were treated with Luohuoxi in the same period were selected.According to the medication method,the patients were divided into 2 groups,namely,Xuanning group and Luohuoxi group,and the clinical efficacy of the 2 groups was observed.Results Thirty-one patients in Xuanning group dropped out of the study due to their own reasons.The blood pressure of the 2 groups after treatment significantly decreased than before treatment,the hypotensive effect of Xuanning group significantly increased than that of Luohuoxi group,and the improvement effect of angina pectoris of Xuanning group significantly increased than that of Luohuoxi group.The incidence of adverse reactions in Xuanning group significantly decreased than that in Luohuoxi group,P<0.05;Multifactor regression analysis showed that Xuanning(OR=0.550,95%CI:0.339-0.894)and baseline diastolic blood pressure(DBP)(OR=0.979,95%CI:0.959-0.999)were protective factors for reducing the incidence of adverse reactions.Cerebrovascular disease(OR=2.651,95%CI:1.651-4.258)was a risk factor for increased adverse reactions.Conclusion The antihypertensive effect and anti-angina effect of Xuanning in patients with hypertension complicated with angina pectoris is better than that of Luohuoxi,which can effectively reduce the risk of adverse reactions,and has the advantages of long-term,safety and convenience.It has high applicability in patients with hypertension complicated with angina pectoris,and is worthy of promotion.

关 键 词：马来酸左旋氨氯地平分散片(玄宁) 苯磺酸氨氯地平片(络活喜) 高血压 心绞痛 

分 类 号：R972[医药卫生—药品]