琥珀酸与代谢性疾病的研究进展  

The advanced research of succinate in metabolic diseases

作　　者：贺喆 危当恒 唐惠芳[1,3,4] HE Zhe;WEI Dangheng;TANG Huifang(Department of Cardiology,the First Affiliated Hospital,University of South China,Hengyang,Hunan 421001,China;Institute of Cardiovascular Diseases,University of South China,Hengyang,Hunan 421001,China;Clinical Research Center for Myocardial Injury in Hunan Province,Hengyang,Hunan 421001,China;Institute of Cardiovascular Diseases,the First Affiliated Hospital,University of South China,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学附属第一医院心内科,湖南省衡阳市421001 [2]南华大学心血管疾病研究所,湖南省衡阳市421001 [3]湖南省心肌损伤临床医学研究中心,湖南省衡阳市421001 [4]南华大学附属第一医院心血管疾病研究所,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2022年第5期454-460,共7页Chinese Journal of Arteriosclerosis

基　　金：湖南省技术创新引导计划-临床医疗技术创新引导项目(2018SK51603);湖南省卫健委项目(B2019122);湖南省卫健委重点指导课题(20201920);湖南省科技创新重点工程项目(2020SK1013-2);湖南创新型省份建设专项经费(2020SK4008);衡阳市科技局新冠肺炎防治基础研究专项项目(202010031573);南华大学新冠肺炎疫情防控应急专项项目(2020-17)。

摘　　要：琥珀酸是细胞线粒体三羧酸循环的中心代谢产物,同时也是肠道菌群重要的代谢产物。大量证据表明琥珀酸以“信号分子”的方式参与代谢性疾病的发生、发展以及转归。肥胖、非酒精性肝炎、2型糖尿病、代谢性心血管疾病与代谢稳态失衡密切相关,本文综述了琥珀酸与这4种代谢性疾病之间的关系及其作用机制,以期为代谢性疾病的预防和治疗提供新的思路和策略。Succinate is the central metabolite of the mitochondrial tricarboxylic acid cycle and an important metabolite of the intestinal flora.Recent studies have showed that succinate involved in the occurrence,development and outcome of metabolic diseases via“signal molecules”.Obesity,non-alcoholic hepatitis,type 2 diabetes mellitus and metabolic cardiovascular disease are closely related to metabolic homeostasis.This article reviews the relationship between succinate and these four metabolic diseases,and its underlying mechanisms,which might benefit to provide new ideas and strategies for the prevention and treatment of metabolic diseases.

关 键 词：琥珀酸 代谢性疾病 肠道菌群 代谢调节剂 

分 类 号：R5[医药卫生—内科学]