阿利吉仑的药理作用和临床应用研究进展  

Research Progress Pharmacological Effects and Clinical Application of Aliskiren

作　　者：梁业飞[1] 

机构地区：[1]钦州市第一人民医院,广西钦州535000

出　　处：《大众科技》2022年第3期63-66,53,共5页Popular Science & Technology

基　　金：“硫酸镁复合罗哌卡因腹横肌平面阻滞在腹腔镜直肠癌患者的术后镇痛研究”(Z20200219)。

摘　　要：高血压老年患者大多合并多种疾病,存在多种药物合用,达到降压目标依然面临着挑战,因此老年高血压的药物治疗一直是研究的热点。阿利吉仑是首个上市的口服直接肾素抑制剂,可直接降低肾素的活性,作用于肾素-血管紧张素系统。阿利吉仑作为抗高血压药物,起效快,降压效果确切,具有心血管和肾脏的保护作用。文章综合国内外文献,探讨阿利吉仑药理作用及其多样性和临床应用。Most elderly patients with hypertension are complicated with a variety of diseases, and there are a variety of drugs in combination. Meeting the goal of reducing blood pressure is still facing challenges. Therefore, the drug treatment of elderly hypertension has always been a research hotspot. Aliskiren is the first listed oral direct renin inhibitor, which can directly reduce the activity of renin and act on the renin angiotensin system. As an antihypertensive drug, Aliskiren has rapid effect and definite antihypertensive effect. It has the protective effects of cardiovascular and kidney. The clinical application and research of aliskiren are less in China. This paper summarizes the literature at home and abroad to explore the pharmacological effects, diversity and clinical application of Aliskiren.

关 键 词：阿利吉仑 高血压 直接肾素抑制剂 药理作用 临床应用 

分 类 号：R97[医药卫生—药品]