超声超微血流成像技术评估颈内动脉粥样硬化斑块新生血管的应用价值  

Application Value of Ultrasonic Ultra-micro Blood Flow Imaging to Evaluate the Neovascularization in Carotid Atherosclerotic Plaque

作　　者：孙檬 SUN Meng(The First Hospital of Dandong,Liaoning Province,Dandong 118000,China)

机构地区：[1]辽宁省丹东市第一医院,辽宁丹东118000

出　　处：《中国医学创新》2022年第7期159-163,共5页Medical Innovation of China

摘　　要：目的:探讨超声超微血流成像技术(SMI)评估颈内动脉粥样硬化斑块新生血管的临床应用价值。方法:选取丹东市第一医院2018年1月-2020年1月常规超声检查确诊为颈动脉粥样硬化斑块的80例(92个斑块)患者。所有患者均行超声造影(CEUS)与SMI检查,比较SMI、CEUS对新生血管的检出情况。根据是否为脑梗死将患者分为脑梗死组(37例)和非脑梗死组(43例),比较两组行SMI检查颈动脉斑块情况。结果:SMI及CEUS检测颈动脉粥样硬化内斑块新生血管情况,差异无统计学意义(P>0.05);SMI及CEUS检测颈动脉粥样硬化内斑块新生血管分级情况比较,差异无统计学意义(P>0.05)。92个斑块中,斑块厚度<2.5 mm有29个,斑块厚度为2.5~3.5 mm有32个,斑块厚度为>3.5 mm有31个。SMI及CEUS检测的颈动脉粥样硬化内斑块厚度与新生血管分级均呈正相关(r;=0.684、0.704,P=0.005、0.017)。脑梗死组颈动脉粥样硬化不稳定斑块数量与SMI评分均高于非脑梗死组(P<0.05)。结论:颈动脉粥样硬化内斑块厚度与新生血管分级呈正相关,SMI和CEUS均可用于检测颈动脉粥样硬化内斑块新生血管形成,但SMI检测技术无需使用造影剂辅助,为临床提供无创便捷诊疗方法,值得临床推广应用。Objective: To evaluate the clinical value of ultrasound superb micro-vascular imaging(SMI) in evaluating the neovascularization in carotid atherosclerotic plaque. Method: A total of 80 patients(92 plaques) with carotid atherosclerotic plaque confirmed by conventional ultrasound examination in First Hospital of Dandong from January 2018 to January 2020 were selected. All patients underwent contrast-enhanced ultrasound(CEUS) and SMI to compare the detection of neovascularization by SMI and CEUS. According to cerebral infarction, patients were divided into cerebral infarction group(37 cases) and non-cerebral infarction group(43 cases), and the two groups underwent SMI to check the carotid plaque status. Result: There was no significant difference between SMI and CEUS in the detection of neovascularization in carotid atherosclerotic plaque(P>0.05). There was no significant difference in the classification of neovascularization in carotid atherosclerotic plaque detected by SMI and CEUS(P>0.05). Among the 92 plaques, 29 plaques were less than 2.5 mm thick, 32 plaques were 2.5-3.5 mm thick, and 31 plaques were more than 3.5 mm thick. The thickness of carotid atherosclerotic plaque was positively correlated with the grade of neovascularization detected by SMI and CEUS(rs=0.684, 0.704, P=0.005, 0.017). The number of atherosclerotic unstable plaque and SMI score in cerebral infarction group were higher than those in non-cerebral infarction group(P<0.05). Conclusion: The thickness of plaque in carotid atherosclerosis is positively correlated with the grade of neovascularization. SMI and CEUS can be used to detect the neovascularization of plaque in carotid atherosclerosis. SMI detection technology does not require the use of contrast agent, which provides noninvasive and convenient clinical diagnosis and treatment, it is worthy of clinical application.

关 键 词：超声超微血流成像技术 脑梗死 颈内动脉粥样硬化 斑块稳定性 

分 类 号：R445.1[医药卫生—影像医学与核医学] R743.33[医药卫生—诊断学]