尿毒清颗粒保留灌肠辅助治疗对CRF患者的肾功能、营养免疫相关血清学指标的影响  

Effects of renal function,nutritional immunity-related serological indexes of Niaoduqing Granules retention enema adjuvant therapy in patients with CRF

作　　者：李进 王博[1] 石岩[1] LI Jin;WANG Bo;SHI Yan(Research Institute of Chinese Medicine,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)

机构地区：[1]辽宁中医药大学中医药科学院,沈阳110847

出　　处：《新疆医科大学学报》2022年第4期455-459,共5页Journal of Xinjiang Medical University

基　　金：国家中医药考试2021年度科研课题(TA2021006)。

摘　　要：目的探讨尿毒清颗粒保留灌肠辅助治疗慢性肾功能衰竭(Chronic renal failure,CRF)患者的临床疗效及肾功能、营养免疫相关血清学指标变化。方法选择2019年4月-2021年4月辽宁中医药大学附属第二医院收治的192例CRF患者作为研究对象,按照随机数字表法分为对照组和观察组,各组96例。两组患者均接受常规治疗,对照组患者在常规治疗基础上接受爱西特保留灌肠辅助治疗,观察组患者则接受尿毒清颗粒保留灌肠辅助治疗。比较两组患者治疗前后的血清学指标变化以及临床疗效。结果与治疗前相比,治疗后两组患者血肌酐(Serum creatinine,Scr)、血尿素氮(Blood urea nitrogen,BUN)水平均明显降低,且观察组患者明显低于对照组患者(P<0.05),肌酐清除率(Creatinine clearance,Ccr)水平均明显升高,且观察组患者明显高于对照组患者(P<0.05)。与治疗前相比,治疗后两组患者CD_(3)^(+)、NK、CD_(4)^(+)/CD_(8)^(+)、CD_(4)^(+)水平均明显升高,且观察组患者明显高于对照组患者(P<0.05)。与治疗前相比,治疗后两组患者血红蛋白(Hemoglobin,Hb)、血清白蛋白(Serum albumin,ABL)、转铁蛋白(Transferrin,TRF)水平均明显升高,且观察组患者明显高于对照组患者(P<0.05)。与治疗前相比,治疗后两组患者硫酸吲哚酚(Indoleol sulfate,IS)和硫酸对甲酚(P-cresol sulfate,PCS)水平均明显降低,且观察组患者明显低于对照组患者(P<0.05)。观察组患者临床疗效总有效率明显高于对照组患者(P<0.05)。结论尿毒清颗粒保留灌肠可降低Scr、BUN水平,提高营养免疫相关的血清学指标水平,清除蛋白结合型毒素,延缓肾功能衰竭进展。Objective To explore the clinical efficacy of Niaoduqing Granules retention enema adjuvant therapy for pa⁃tients with chronic renal failure(CRF)and the changes of renal function,and nutritional immunity-related serological indexes.Methods 192 patients with CRF treated in our hospital from April 2019 to April 2021 were randomly divided into control group(n=96)and observation group(n=96).Patients in both groups received routine treatment.Patients in the control group received adjuvant treatment with Aicite retention enema on this basis of routine treatment,while pa⁃tients in the observation group received adjuvant treatment with Niaoduqing Granules retention enema.The changes of serological indexes and clinical efficacy of the two groups before and after treatment were compared.Results Com⁃pared with before treatment,the levels of serum creatinine(Scr)and blood urea nitrogen(BUN)in the two groups were significantly lower after treatment,and the patients in the observation group was significantly lower than that in the con⁃trol group(P<0.05),creatinine clearance(Ccr)level was significantly higher in the observation group than that in the control Group(P<0.05).Compared with before treatment,the levels of CD3+,NK,CD4+/CD8+and CD4+in the two groups increased significantly after treatment,and the levels in the observation group were significantly higher than those in the control group(P<0.05).Compared with before treatment,the levels of hemoglobin(Hb),serum albumin(ABL)and transferrin(TRF)in the two groups were significantly higher after treatment,and the levels in the observa⁃tion group were significantly higher than those in the control group(P<0.05).Compared with before treatment,the lev⁃els of indoleol sulfate(IS)and p-cresol sulfate(PCS)in both groups decreased significantly after treatment,and the lev⁃els in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate of clinical efficacy in the observation group was significantly higher than that in

关 键 词：尿毒清颗粒 慢性肾功能衰竭 保留灌肠 血清学指标 

分 类 号：R692.5[医药卫生—泌尿科学]