广州市钢铁行业中青年男性代谢综合征与外周血白细胞的关联性  

Correlation between white blood cell count and metabolic syndrome in young and middle-aged male employees in steel industry in Guangzhou

作　　者：莫沛[1] 黎佼[1] 钟赟[1] 刘世明[1] 吴峻宇 高芳[3] 裴静娴[1] Mo Pei;Li Jiao;Zhong Yun;Liu Shiming;Wu Junyu;Gao Fang;Pei Jingxian(Department of Cardio Vascular Medicine,Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China;Department of Neurology,Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China;Health Management Center,Binzhou People's Hospital,Binzhou 256600,China)

机构地区：[1]广州医科大学附属第二医院心血管科,广州510260 [2]广州医科大学附属第二医院神经内科,广州510260 [3]滨州市人民医院健康管理中心,滨州256600

出　　处：《国际医药卫生导报》2022年第9期1218-1221,共4页International Medicine and Health Guidance News

基　　金：广东省医学科学技术研究基金项目(A2018347);广州市医药卫生科技项目(20171A011306);广州市卫生和计划生育科技项目(20182A011019、202002030336)。

摘　　要：目的了解广州市钢铁从业中青年男性人群代谢综合征(MS)与白细胞计数(WBC)的关联性。方法本研究为横断面研究。整群随机抽取2009年广州市某钢铁集团16个单位4241名员工进行问卷调查和体检,其中男3760人,年龄(38.400±10.258)岁。将研究对象根据WBC分为3组[WBC(3.40~5.70)×10^(9)/L:1162人,(>5.70~6.90)×10^(9)/L:1196人,>6.90×10^(9)/L:1402人],采用相关分析研究WBC与MS相关组分之间的关联性,采用多因素logistic回归,分析随着WBC的升高,MS患病率的变化。结果多因素logistic回归结果显示,在校正了年龄、吸烟、喝酒等因素后,随着WBC的水平升高,MS患病风险增加,与WBC最低值比较,第2组和第3组的OR值分别为1.88和2.58,差异有统计学意义(P<0.05)。结论WBC在广州钢铁从业中青年男性MS及代谢异常组的水平升高,可能是MS的独立危险因素。Objective To understand the association between metabolic syndrome(MS)and white blood cell count(WBC)in young and middle-aged men in steel industry in Guangzhou.Methods This was a cross-sectional study.A total of 4241 employees who worked at 16 units of some steel group in 2009 in Guangzhou were selected by the cluster random sampling for questionnaire survey and physical examination,including 3760 males,and they were(38.400±10.258)years old.According to the WBC,they were divided into 3 groups[WBC(3.40~5.70)×10^(9)/L:1162 persons,(>5.70~6.90)×10^(9)/L:1196 persons,>6.90×10^(9)/L:1402 persons].The correlation analysis was used to study the correlation between WBC and MS-related components.Multivariate logistic regression was used to analyze the change of MS prevalence as the WBC increased.Results The multivariate logistic regression results showed that after adjusting age,smoking,drinking,and other factors,as the WBC increased,the risk of MS increased.Compared with the lowest value of WBC,the OR values of the second and third groups were 1.88 and 2.58,respectively,with a statistical difference(P<0.05).Conclusion WBC increases in the metabolic syndrome and metabolic abnormal groups of young and middle-aged male steel workers in Guangzhou,and may be an independent risk factor for MS.

关 键 词：代谢综合征 心血管疾病 白细胞 

分 类 号：R589[医药卫生—内分泌]