肉桂醛改善糖代谢作用靶点及生物信息学分析  

Targets of cinnamaldehyde in improving glucose metabolism and bioinformatics analysis

作　　者：徐丽华 刘银河 钟篇 张海林 王丽丽 钟泳滢 赵洪磊 XU Lihua;LIU Yinhe;ZHONG Pian;ZHANG Hailin;WANG Lili;ZHONG Yongying;ZHAO Honglei(Department of Pharmacy,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen,Guangdong,Shenzhen 518000,China;Department of Laboratory Medicine,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen,Guangdong,Shenzhen 518000,China;Department of Endocrinology,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen,Guangdong,Shenzhen 518000,China;Department of Traditional Chinese Medicine,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen,Guangdong,Shenzhen 518000,China;Department of Cardiology,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen,Guangdong,Shenzhen 518000,China;Clinical Medicine Research Center,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen,Guangdong,Shenzhen 518000,China)

机构地区：[1]深圳市中国医学科学院阜外医院深圳医院药剂科,广东深圳518000 [2]深圳市中国医学科学院阜外医院深圳医院检验科,广东深圳518000 [3]深圳市中国医学科学院阜外医院深圳医院内分泌科,广东深圳518000 [4]深圳市中国医学科学院阜外医院深圳医院中医科,广东深圳518000 [5]深圳市中国医学科学院阜外医院深圳医院心内科,广东深圳518000 [6]深圳市中国医学科学院阜外医院深圳医院临床医学研究中心,广东深圳518000

出　　处：《中国医药科学》2022年第7期57-60,97,共5页China Medicine And Pharmacy

基　　金：广东省深圳市科技计划项目(JCYJ20210324125002006)。

摘　　要：目的利用数据挖掘构建组合网络,通过生物信息学分析获取肉桂醛改善糖代谢作用靶点。方法首先应用网络药理学方法挖掘出数据库中肉桂醛改善糖代谢作用的32条通路;再基于R软件包“graphite”将数据库中的通路转换为生物网络,在线进行富集分析;然后用Cytoscape构建代谢组学与网络药理学的组合网络;最后推测改善糖代谢作用的关键靶点和潜在的关联机制。结果筛选出10个与肉桂醛改善糖代谢有关的关键靶点,其中IRS-1、AMPK-1、AMPK-2、PRKAB-1和PRKAB-2这5个靶点最有可能受肉桂醛调控。结论采用网络比较和比对方法建立生物通路组合网络,分析肉桂醛的候选关键靶点的方法是有效可行的。Objective To construct a combinatorial network by data mining and obtain the targets of cinnamaldehyde in improving glucose metabolism through bioinformatics analysis.Methods Firstly,32 pathways of cinnamaldehyde in improving glucose metabolism in the database were excavated by the network pharmacology method.Then the pathways in the database were transformed into biological networks based on R software package"graphite",and enrichment analysis was carried out online.Cytoscape was used to construct a combinatorial network of metabonomics and network pharmacology afterwards.Finally,the key targets and potential correlation mechanisms in improving glucose metabolism were speculated.Results Ten key targets related to improving glucose metabolism by cinnamaldehyde were screened,among which IRS-1,AMPK-1,AMPK-2,PRKAB-1 and PRKAB-2 were most likely regulated by cinnamaldehyde.Conclusion It is effective and feasible to establish a combinatorial network of biological pathways by network comparison and comparative method to analyze the candidate key targets of Cinnamaldehyde.

关 键 词：肉桂醛 糖代谢 生物途径 组合网络 

分 类 号：R285[医药卫生—中药学]