妊娠期糖尿病患者肠道菌群、反应性充血指数与母婴结局的相关研究  

Study on the correlation between intestinal flora,reactive hyperemia index and maternal-infant outcomes in patients with gestational diabetes mellitus

作　　者：许小欢 郭丽华 赖晨晖 XU Xiaohuan;GUO Lihua;LAI Chenhui(Department of Obstetrics,Shiyan People’s Hospital of Baoan District in Shenzhen City,Guangdong,Shenzhen 518100,China)

机构地区：[1]深圳市宝安区石岩人民医院产科,广东深圳518100

出　　处：《中国医药科学》2022年第7期116-119,共4页China Medicine And Pharmacy

基　　金：广东省深圳市宝安区科技计划基础研究项目(医疗卫生类)(2021JD225)。

摘　　要：目的研究妊娠期糖尿病(GDM)患者肠道菌群、反应性充血指数(RHI)与母婴结局的相关性。方法选取深圳市宝安区石岩人民医院产科2020年9月至2021年9月定期产检并住院足月分娩的120例GDM孕妇,设为研究组,另选取本院同时期定期产检并住院足月分娩的80例血糖正常孕妇,设为对照组;对两组孕妇进行肠道菌群、RHI检测,对比分析其检测结果;同时对研究组孕妇进行随访,根据母婴结局分为A组(正常妊娠组)、B组(不良妊娠组),对比两组的肠道菌群、RHI差异。结果研究组孕妇肠杆菌、肠球菌的菌落数均大于对照组,双歧杆菌、乳杆菌的菌落数以及RHI值均小于对照组,差异有统计学意义(P<0.05)。研究组120例孕妇中,发生不良妊娠事件34例,不良妊娠发生率为28.33%;B组产妇肠杆菌、肠球菌的菌落数均大于A组,双歧杆菌、乳杆菌的菌落数以及RHI值均小于A组,差异有统计学意义(P<0.05)。结论GDM患者肠道菌群、RHI与母婴结局之间存在一定的相关性,对肠道菌群、RHI进行检测,有助于临床评估不良妊娠,对提高产科分娩质量有一定的促进作用。Objective To study the correlation between intestinal flora,reactive hyperemia index(RHI)and maternal-infant outcomes in patients with gestational diabetes mellitus(GDM).Methods A total of 120 pregnant women with GDM who received regular prenatal examinations and were hospitalized with full-term delivery in the Department of Obstetrics of Shiyan People’s Hospital of Baoan District in Shenzhen City from September 2020 to September 2021 were selected as the study group,and another 80 pregnant women with normal blood glucose who received regular prenatal examinations and were hospitalized with full-term delivery in the hospital during the same period were selected as the control group.The intestinal flora and RHI in the two groups were detected and the detection results were comparatively analyzed.The pregnant women in the study group were followed up and divided into group A(the normal pregnancy group)and group B(the adverse pregnancy group)according to the maternal-infant outcomes,and the differences in intestinal flora and RHI were compared between the two groups.Results The colony counts of Enterobacteriaceae and Enterococcus were greater,and the colony counts of Bifidobacterium and Lactobacillus as well as the RHI values were smaller in the study group than those in the control group,with statistically significant differences(P<0.05).Among 120 pregnant women in the study group,34 cases developed adverse pregnancy events,with an incidence of adverse pregnancy of 28.33%.The colony counts of Enterobacteriaceae and Enterococcus were greater,and the colony counts of Bifidobacterium and Lactobacillus as well as the RHI values were smaller in group B than those in group A,with statistically significant differences(P<0.05).Conclusion There is a correlation between intestinal flora,RHI and maternal-infant outcomes in patients with GDM,and the detection of intestinal flora and RHI is helpful for clinical assessment of adverse pregnancy and is contributes to improving the quality of obstetric delivery.

关 键 词：妊娠期糖尿病 肠道菌群 反应性充血指数 母婴结局 相关性 

分 类 号：R714.25[医药卫生—妇产科学]