中性粒细胞与淋巴细胞的比值运用在早期糖尿病肾脏疾病患者中的效果  

Effect of neutrophil-to-lymphocyte ratio on patients with early diabetic kidney disease

作　　者：卢丽珊 卢新兆 林卫 LU Lishan;LU Xinzhao;LIN Wei(Department of Clinical Laboratory,Longyan First Hospital Affiliated to Fujian Medical University,Fujian,Longyan 364000,China)

机构地区：[1]福建医科大学附属龙岩第一医院检验科,福建龙岩364000

出　　处：《中国医药科学》2022年第7期142-145,178,共5页China Medicine And Pharmacy

摘　　要：目的探讨中性粒细胞与淋巴细胞比值(NLR)在早期糖尿病肾脏疾病(DKD)患者中的效果评价。方法收集福建医科大学附属龙岩第一医院2020年6月至2021年6月共103例糖尿病患者作为观察组,观察组根据24 h尿白蛋白量分为单纯糖尿病(DM)患者21例,早期DKD患者25例以及临床DKD患者57例,选取同期32名健康体检者作为对照组。收集全部研究对象的空腹血液样本和24 h尿液标本,分别进行全血细胞分析、血清胱抑素C(Cys C)和24 h尿总蛋白的检测,计算出NLR,比较各组NLR、Cys C和24 h尿总蛋白的水平,分析检测结果。结果对照组和DM组、早期DKD组、临床DKD组的NLR水平分别为(1.49±0.39)、(1.78±0.56)、(2.36±0.89)、(2.76±0.71);Cys C水平分别为(0.65±0.13)、(0.83±0.20)、(1.82±0.23)、(2.71±0.59)mg/L;24 h尿总蛋白水平分别为(58.44±16.93)、(77.84±35.58)、(300.20±96.46)、(2933.85±2971.62)mg/d;观察组各项检测结果与对照组比较均明显升高,差异有统计学意义(P<0.05),且DM组、早期DKD组和临床DKD组均呈现依次升高,差异有统计学意义(P<0.05)。结论NLR运用在中国早期糖尿病肾脏疾病的诊断及治疗中具有非常重要的价值,有助于提高糖尿病肾脏疾病的早期诊断,改善患者预后。Objective To investigate the evaluation of the effect of neutrophil-to-lymphocyte ratio(NLR)on patients with early diabetic kidney disease(DKD).Methods A total of 103 patients with diabetes mellitus(DM)at the Longyan First Hospital Affiliated to Fujian Medical University from June 2020 to June 2021 were selected as the observation group and divided into 21 patients with DM,25 patients with early DKD,and 57 patients with clinical DKD according to the 24-hour urinary albumin quantification.Meanwhile,32 subjects with healthy physical examination were selected as the control group during the same period.The fasting blood samples and 24-hour urine specimens were collected from all study subjects to conduct the whole blood cell analysis and the testing for serum cystatin C(Cys C)and 24-hour total urine protein.The NLR was calculated,the levels of NLR,Cys C and 24-hour total urine protein were compared among all groups,and the test results were analyzed.Results The values of NLR were(1.49±0.39),(1.78±0.56),(2.36±0.89)and(2.76±0.71),the levels of Cys C were(0.65±0.13)mg/L,(0.83±0.20)mg/L,(1.82±0.23)mg/L,and(2.71±0.59)mg/L,and the levels of 24-hour total urine protein were(58.44±16.93)mg/d,(77.84±35.58)mg/d,(300.20±96.46)mg/d,and(2933.85±2971.62)mg/d in the control,DM,early DKD and clinical DKD groups,respectively.The results of each test index were significantly higher in the observation group than those in the control group,with statistically significant differences(P<0.05).The above-mentioned test indexes all showed a sequential increase in the DM group,early DKD group and clinical DKD group,with statistically significant differences(P<0.05).Conclusion The NLR is of great value in the diagnosis and treatment of early DKD in China,which helps to improve the early diagnos is rate of DKD and improve the prognosis.

关 键 词：中性粒细胞与淋巴细胞比值 胱抑素C 24 h尿蛋白 早期糖尿病肾脏疾病 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]