广州社区高血压控制满意患者颈动脉斑块转归分析  

Outcome analysis of carotid plaque in patients with satisfactory hypertension control in Guangzhou communities

作　　者：杨东恒 朱启科 叶博文 邓海雅 符姝姝 莫明树[2] 徐评议[2] 田作军[2] Yang Dongheng;Zhu Qike;Ye Bowen;Deng Haiya;Fu Shushu;Mo Mingshu;Xu Pingyi;Tian Zuojun(The First Clinical College,Guangzhou Medical University,Guangzhou 510160,China;Department of Neurology,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]广州医科大学第一临床学院,广州510160 [2]广州医科大学附属第一医院神经内科,广州510120

出　　处：《国际医药卫生导报》2022年第10期1333-1337,共5页International Medicine and Health Guidance News

基　　金：广东省科技厅社会发展项目(2013B021800282,2014A020212350);广州市重点学科财政补助项目(0332100000093)。

摘　　要：目的探讨广州社区高血压控制满意患者颈动脉斑块的临床转归。方法连续收集2016年1月至2019年12月在广州医科大学附属第一医院神经内科在半年至1年内两次住院且均作颈动脉超声检测的广州社区患者326例,其中男166例、女160例,年龄(71.17±0.60)岁。分为非高血压(56例)、高血压控制满意(195例)和高血压控制不满意(75例)3组,比较颈动脉斑块的临床转归(△Crouse评分);再将资料分为70岁以下和70岁及以上两个层次进一步分析3组间斑块的转归;最后,将高血压患者再分为高血压两次控制满意(160例)、一次控制满意(35例)和两次控制均不满意(75例)3个亚组,分析斑块的转归情况。计量资料采用单因素ANOVA或Kruskal-Wallis法检验,计数资料采用χ^(2)检验。结果高血压控制满意组和非高血压组间△Crouse评分差异无统计学意义(P>0.05);但高血压控制不满意组与高血压控制满意组、非高血压组之间△Crouse评分差异均有统计学意义[0.400(0.000,1.900)分比0.000(-0.200,0.700)分比0.000(-0.200,0.200)分](均P<0.05)。在70岁以下和70岁及以上患者中高血压控制满意患者与非高血压患者间△Crouse评分差异均无统计学意义(均P>0.05)。3个高血压亚组中,高血压两次控制满意组与两次控制不满意组间△Crouse评分差异有统计学意义(P<0.05),其他分组间差异无统计学意义(P>0.05)。结论对所有年龄的高血压患者,血压控制满意后,颈动脉斑块进展情况与非高血压患者无明显差别;但血压控制不满意患者颈动脉斑块的进展明显增快。Objective To investigate the clinical outcome of carotid plaque in patients with satisfactory hypertension control in Guangzhou communities.Methods From January 2016 to December 2019,326 patients in Guangzhou communities were continuously recruited in the study,they were hospitalized in Department of Neurology,The First Affiliated Hospital of Guangzhou Medical University and also underwent carotid ultrasonography twice within half a year to one year.There were 166 males and 160 females,aged(71.17±0.60)years.The patients were divided into a non-hypertension group(NH group,56 cases),a satisfactory hypertension control group(SH group,195 cases),and an unsatisfactory hypertension control group(USH group,75 cases).The clinical outcomes of carotid plaque(△Crouse score)of the three groups were compared.Then,a stratified analysis of△Crouse score was performed between younger than and equal to or older than 70 years old among the above three groups.Finally,the hypertensive patients were further subdivided into three subgroups of hypertension with satisfactory control twice(160 cases),satisfactory control once(35 cases),and unsatisfactory control twice(75 cases)to analyze the△Crouse score.The measurement data were tested by one-way ANOVA or Kruskal-Wallis method,and the count data were tested byχ^(2) test.Results There was no statistically significant difference in the△Crouse score between the SH group and the NH group(P>0.05);there was a statistically significant difference in the△Crouse score between the USH group and the SH group or the NH group[0.400(0.000,1.900)points vs.0.000(-0.200,0.700)points vs.0.000(-0.200,0.200)points](both P<0.05).There were no statistically significant differences in the△Crouse score between the SH group and the NH group in patients younger than and equal to or older than 70 years old(both P>0.05).Among the three hypertensive subgroups,there was statistically significant difference in the△Crouse score between the two subgroups with and without satisfactory hypertension control

关 键 词：高血压 颈动脉斑块 颈动脉超声 社区研究 

分 类 号：R544.1[医药卫生—心血管疾病]