FGF23/Klotho在急性肾损伤中的研究进展  

FGF23 and Klotho in AKI update

作　　者：廖甄楠 李强 宋卓恒 曹锐[1] 李伟龙[1,3] 王洁 戴洪波 栾韶东 胡波 尹良红[1,4] Liao Zhennan;Li Qiang;Song Zhuoheng;Cao Rui;Li Weilong;Wang Jie;Dai Hongbo;Luan Shaodong;Hu Bo;Yin Lianghong(Department of Nephrology,The First Affiliated Hospital of Jinan University,Guangzhou 510000,China;Department of Nephrology,Dongguan Hospital of Traditional Chinese Medicine,Dongguan 523005,China;Department of Nephrology,The Central Hospital of Longhua District,Shenzhen 518110,China;Guangzhou Enttxs Medical Products Co.,Ltd.P.R.,Guangzhou 510663,China)

机构地区：[1]暨南大学附属第一医院肾内科,广州510000 [2]东莞市中医院内十科(肾病),东莞523005 [3]深圳市龙华区中心医院肾内科,深圳518110 [4]广州市恩德氏医疗制品有限公司,广州510663

出　　处：《国际医药卫生导报》2022年第10期1367-1371,共5页International Medicine and Health Guidance News

基　　金：广州市恩德氏院士专家工作站(2019-48);广州开发区创业领军人才项目(2017-L153);广东省血液净化临床工程技术研究中心(507204531040);2019年东莞市社会科技发展(重点)项目(201950715002195)。

摘　　要：急性肾损伤(AKI)在世界范围内具有较高的发病率和病死率,且是慢性肾脏病(CKD)和进展为终末期肾脏病的危险因素,给患者带来日益沉重的健康负担。成纤维生长因子23(FGF23)和a-Klotho(以下称“Klotho”)通路是近年来的研究热点。AKI发生后,血清中FGF23水平迅速上升,Klotho表达下降。这两种指标的变化被认为是预测AKI发生及预后的新型生物预测标志。本文围绕FGF23和Klotho在AKI中的表达改变和相关机制进行综述。Acute kidney injury(AKI)has high morbidity and mortality worldwide,as a risk factor for chronic kidney disease(CKD)and progression to end-stage renal disease(ESRD),which brings an increasingly health burden to patients.Fibroblast growth factor-23(FGF23)and a-Klotho(Klotho)pathways have been emerging as the novel biomarkers to predict the occurrence and prognosis of AKI in recent years.After AKI occurrence,it is found that the level of FGF23 in serum increases and the expression of Klotho decreases.This article reviews the expression changes and related mechanisms of FGF23 and Klotho in AKI.

关 键 词：急性肾损伤 成纤维生长因子23 KLOTHO 

分 类 号：R692[医药卫生—泌尿科学]