非热等离子体诱导肿瘤细胞的损伤和死亡模式  

The damage and death modes in tumor cells induced by non-thermal plasma

作　　者：彭胜杰 陈国栋 韩伟[1,3] PENG Shengjie;CHEN Guodong;HAN Wei(Institute of Health and Medical Technology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China;Science Island Branch,Graduate School of USTC,Hefei 230026,China;Center of Radiotherapy,Cancer Hospital,Chinese Academy of Sciences,Hefei 230031,China)

机构地区：[1]中国科学院合肥物质科学研究院健康与医学技术研究所,安徽合肥230031 [2]中国科学技术大学研究生院科学岛分院,安徽合肥230026 [3]中国科学院合肥肿瘤医院放疗中心,安徽合肥230031

出　　处：《安徽大学学报（自然科学版）》2022年第3期14-23,共10页Journal of Anhui University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(U20A20372)。

摘　　要：非热等离子体杀灭肿瘤细胞具有“广谱”与高效的优势,且能“选择性”杀死肿瘤细胞,有望成为肿瘤治疗的新型物理技术.非热等离子体通过提高细胞内活性氧自由基水平,损伤DNA等生物分子及多个细胞器,启动多条信号通路最终导致细胞进入死亡阶段.笔者主要概述了近年来非热等离子体对肿瘤细胞的损伤及机制、诱导肿瘤细胞发生程序性死亡的类型及相应机制,为其后续研究及临床应用提供参考.Non-thermal plasma has the advantages of “broad-spectrum” and high efficiency in killing tumor cells,especially selectively killing tumor cells,and it is expected to be a new physical method to cancer therapy.Non-thermal plasma increases the level of reactive oxygen species in cells to damage biological molecules such as DNA and various organelles,activate multiple signal pathways,and ultimately leads to cell death.This article summarized the recent progress about the damages and death type of tumor cells including the possible mechanisms induced by non-thermal plasma.We hope it can provide some insights to the further studies and clinical application in the future.

关 键 词：非热等离子体 肿瘤治疗 细胞损伤 程序性细胞死亡 

分 类 号：Q68[生物学—生物物理学]