正交试验法优化发酵虫草菌粉提取工艺及颐神颗粒制备工艺的研究  

Optimization of extraction technology of Fermented Cordyceps powder and preparation technology of Yishen granules by orthogonal test

作　　者：郭增光 王玉栋 陈仁燕 GUO Zeng-guang;WANG Yu-dong;CHEN Ren-yan(Sunhover Pharmaceutical Co.,Ltd.,Linyi 276023,China)

机构地区：[1]翔宇药业股份有限公司,山东临沂276023

出　　处：《中国处方药》2022年第4期31-33,共3页Journal of China Prescription Drug

摘　　要：目的正交试验法优化颐神颗粒中发酵虫草菌粉(Cs-4)提取工艺及制备工艺的研究。方法通过正交试验研究发酵虫草菌粉室温浸提的最佳工艺,及颐神颗粒浓缩、干燥、整粒及混合等工艺研究,并考察连续三批中试生产以验证工艺的可行性及稳定性。结果发酵虫草菌粉最佳提取工艺条件为:以60%乙醇为提取剂,加8倍量60%乙醇室温浸提12 h,60℃~70℃下减压浓缩至相对密度1.20~1.25(70℃~75℃)的清膏。三种清膏混合后控制干燥温度65℃~75℃进行干燥,用12目和50目双层旋涡振荡筛进行整粒。三批中试样品成品率高、各项指标检验合格且工艺稳定。结论建立了一种可工业化制备颐神颗粒的工艺。Objective Optimization of extraction process of Fermented Cordyceps powder from Yishen granules by orthogonal experiment and study on the preparation and technology.Methods The optimum extraction process of Fermented Cordyceps powder at room temperature was studied by orthogonal test,and the concentration,drying,whole grain and mixing process of Yishen granules were studied.Three consecutive batches of pilot production were investigated to verify the feasibility and stability of the process.Results The optimum extraction conditions of Fermented Cordyceps powder were as follows:60%ethanol was used as the extraction agent,8 times of 60%ethanol was added,the extract was extracted at room temperature for 12 hours,and the extract was concentrated at 60℃~70℃to a relative density of 1.20~1.25(70℃~75℃).After mixing the three kinds of ointments,the drying temperature was controlled at 65℃~75℃for drying,and the 12 mesh and 50 mesh double-layer vortex vibrating screen was used for whole grains.The three batches of pilot test samples have high yield,all indexes are qualified and the process is stable.Conclusion A new industrialized process for the preparation of Yishen granules was established.

关 键 词：颐神颗粒 发酵虫草菌粉 正交试验法 

分 类 号：R283.6[医药卫生—中药学]