成人金黄色葡萄球菌肺炎132例危险因素及预后分析  

Risk factor and prognosis profiling in 132 adults with Staphylococcus aureus pneumonia

作　　者：张燕相 周笳 谭效锋[1] ZHANG Yan-xiang;ZHOU Jia;TAN Xiao-feng(Department of Respiratory Medicine,Tianjin Hospital,Tianjin 300211,China)

机构地区：[1]天津市天津医院呼吸科,天津300211

出　　处：《中国处方药》2022年第4期179-181,共3页Journal of China Prescription Drug

摘　　要：目的了解成人金黄色葡萄球菌肺炎的临床特征,探讨影响其预后的独立危险预测因素。方法回顾性分析天津市天津医院2010年1月~2021年5月确诊为金黄色葡萄球菌肺炎132例患者的病历资料并收集潜在危险因素,根据预后情况分成两组,先进行单因素分析,再针对有统计学意义的危险因素,以预后不良为结局变量进行多因素分析,最终得到与金黄色葡萄球菌肺炎预后不良相关的独立危险因素结果132例金黄色葡萄球菌肺炎患者在住院期间预后不良共有11例,其中死亡7例,死亡率为5.3%。单因素分析:年龄>60岁、耐甲氧西林金黄色葡萄球菌(MRSA)感染、机械通气、透析、中心静脉置管、肾功能不全、低蛋白血症7项因素在预后不良组与预后良好组间存在显著差异(P<0.05),是金黄色葡萄球菌肺炎患者预后不良的相关危险因素;多因素回归分析:MRSA感染(OR=9.554,P=0.028)、机械通气(OR=25.437,P=0.015)、透析(OR=40.256,P=0.014)3项是金黄色葡萄球菌肺炎患者预后不良的独立危险因素。结论金黄色葡萄球菌肺炎患者死亡率较高,MRSA感染、机械通气及透析是其预后不良的独立危险因素。Objective To investigate the clinical characteristics of adult Staphylococcus aureus pneumonia,explore the independent risk factors to predict the impact their prognosis.Methods The clinical data of 132 patients with staphylococcus aureus pneumonia,diagnosed from January 2010 to May 2021 in Tianjin Hospital,were retrospectively analyzed.The 132 patients were divided into two groups according to the prognosis,at first use single factor analysis,and then target the statistically significant risk factors,make multivariate analysis with poor prognosis as the outcome variable,eventually get the independent risk factors associated with poor prognosis of Staphylococcus aureus pneumonia.Results During hospitalization of the 132 patients with staphylococcus aureus pneumonia,11 patients have a poor prognosis,7 patients died with a mortality rate of 5.3%.Single factor analysis showed that,there were statistical differences(P<0.05)between the favourable prognosis group and the poor prognosis group in old age(≥60 years),MRSA infection,mechanical ventilation,dialysis,central venous catheter,renal insufficiency and hypoproteinemia.Multivariate analysis showed that MRSA infection(OR=9.554,P=0.028)、mechanical ventilation(OR=9.554,P=0.028)and dialysis(OR=40.256,P=0.014)were independent risk factors for poor prognosis.Conclusion Patients with Staphylococcus aureus pneumonia have a higher mortality rate,MRSA infection、mechanical Ventilation and dialysis are independent risk factors for poor prognosis.

关 键 词：金黄色葡萄球菌 肺炎 预后不良 危险因素 

分 类 号：R563.1[医药卫生—呼吸系统]