超声分子成像技术在靶向诊疗动脉粥样硬化中的进展  

Molecular Ultrasound Imaging Technology for Targeting Diagnosis and Treatment of Atherosclerosis

作　　者：阎文江 陈良[1] 杨晶晶[1] YAN Wenjiang;CHEN Liang;YANG Jingjing(The Key Laboratory of Cardiovascular Remodeling and Function Research,Chinese Ministry of Education,Chinese National Health Commission and Chinese Academy of Medical Sciences,The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China)

机构地区：[1]教育部、国家卫健委、中国医学科学院心血管重构与功能研究重点实验室,省部共建心血管转化医学重点实验室山东大学齐鲁医院,山东济南250012

出　　处：《心血管病学进展》2022年第4期309-312,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金青年基金(81900321)。

摘　　要：动脉粥样硬化是一种无症状的慢性炎症性疾病,最终导致斑块的形成。当斑块不稳定糜烂破裂触发血栓形成,阻塞血管,导致急性心肌梗死和脑卒中。目前,动脉粥样硬化的预防主要通过对危险因素(吸烟、高血压、高血糖和高血脂)的监测和控制。在严格控制危险因素以及强化药物治疗的情况下,剩余风险对临床仍是一个巨大的挑战。更早期检测预防动脉粥样硬化病变,阻止斑块继续发展破裂势在必行。近年来靶向超声微泡发展迅速,超声微泡靶向成像技术可在分子和细胞水平上早期识别和诊断动脉粥样硬化斑块的特征和成分组成,为动脉粥样硬化疾病的治疗提供了更多的机会。Atherosclerosis is an asymptomatic chronic inflammatory disease,which eventually leads to the formation of plaque.When an unstable plaque suddenly ruptures,it triggers the formation of thrombi which leading to acute myocardial infarction and stroke by blocking the vessels.Currently,the prevention of atherosclerosis is mainly through monitoring and control of the risk factors(smoking,hypertension,hyperglycemia and hyperlipidemia).Residual risk remains a huge clinical challenge in the context of strict control of risk factors and intensive drug therapy.Therefore,early detection and prevention of atherosclerotic lesions and preventing the continued development of plaque rupture are imperative.In the past few years,the microbubbles functionalized with different targeting ligands to assess different stages of atherosclerosis has been successfully introduced in the preclinical applications.This technology has the potential to substantially improve the precision in the diagnosis and treatment of atherosclerosis.

关 键 词：动脉粥样硬化 靶向超声微泡 内皮细胞 血管新生 

分 类 号：R54[医药卫生—心血管疾病]