布地奈德联合桉柠蒎在促进慢性鼻窦炎患者快速康复中的作用  

Effects of budesonide suspension combined with Eucalyptol,Limonene and Pinene Enteric Soft Capsules in promoting rapid recovery of patients with chronic rhinosinusitis

作　　者：蔡靖 盛菊萍[2] 陆赛男[2] 杨男男 曹慧[3] 张洁[2] CAI Jing;SHENG Juping;LU Sainan;YANG Nannan;CAO Hui;ZHANG Jie(Department of Otolaryngology Head and Neck Surgery,the People's Hospital of Rugao,Jiangsu Province,Rugao 226500;Department of Otolaryngology Head and Neck Surgery,the Affiliated Hospital of Nantong University;Department of Anesthesia and Surgery,the Affiliated Hospital of Nantong University)

机构地区：[1]江苏省如皋市人民医院耳鼻咽喉头颈外科,如皋226500 [2]南通大学附属医院耳鼻咽喉头颈外科 [3]南通大学附属医院麻醉手术科

出　　处：《南通大学学报（医学版）》2022年第1期39-42,共4页Journal of Nantong University(Medical sciences)

基　　金：南通市科技项目(JC2020064)。

摘　　要：目的:探讨鼻内镜术后不同填塞材料联合药物治疗在术腔恢复中的应用效果。方法:将2019年3月—2020年3月在南通大学附属医院耳鼻咽喉头颈外科住院的慢性鼻窦炎150例患者随机分为5组,每组30例。所有患者行功能性内镜鼻窦手术后,A组采用膨胀海绵填塞;B组采用纳吸棉填塞;C组采用吸入布地奈德混悬液1 mL浸润的纳吸棉填塞;D组在B组基础上口服桉柠蒎肠溶软胶囊;E组在C组基础上口服桉柠蒎肠溶软胶囊。对5组患者心理状态、视觉模拟量表(visual analogue scale,VAS)、黏膜恢复情况、嗅觉功能、鼻腔阻力、术后出血量以及复发的情况进行分析。结果:(1)术后第1天,A组患者焦虑评分高于其余4组(P<0.05)。(2)术后1~2 d,A组VAS评分高于其余4组(P<0.05),术后3天和1周,E组的VAS评分优于D组(P<0.05)。(3)术后2周时,B、E组Lund-Kennedy评分分别与C、D组比较差异有统计学意义(P<0.05),术后1、2个月,E组Lund-Kennedy评分较C、D组低(P<0.05)。(4)相比A组,B、C、D、E组对嗅觉功能的恢复在各个时期均有促进作用(P<0.05);而E组在术后2周及2个月时对嗅觉功能的恢复较其他组更显著(P<0.05)。(5)相比A组,B、C、D、E组对鼻腔阻力的降低在术后2周及1个月均有促进作用(P<0.05),E组较B、D组在各个时期的鼻阻力低(P<0.05)。(6)B、C、D、E组术毕72 h出血量少于A组(P<0.05)。(7)各组的术后复发率差异无统计学意义(P>0.05)。结论:用含有布地奈德混悬液的纳吸棉填塞术腔联合桉柠蒎肠溶软胶囊干预可促进鼻窦炎患者的术后快速恢复,值得推广。Objective:To investigate the application effect of different packing materials combined with drug therapy in the recovery of surgical cavity after endoscopic sinus surgery.Methods:The 150 patients with chronic rhinosinusitis who were hospitalized in the Department of Otolaryngology Head and Neck Surgery,the Affiliated Hospital of Nantong University from March 2019 to March 2020 were randomly divided into 5 groups with 30 cases in each group.After all patients underwent functional endoscopic sinus surgery,in group A,only expansion sponge was used for tamponade;group B was only used to tampon with nanoabsorbent cotton;group C was tamponed with nasopor infused with 1 mL of budesonide suspension for inhalation;group D was treated with oral eucalyptol limonene pinene enteric soft capsules(Eucalyptol,Limonene and Pinene Enteric Soft Capsules)based on group B;group E was supplemented with the intervention of Eucalyptol,Limonene and Pinene Enteric Soft Capsules on the basis of group C.The psychological status,visual analogue scale(VAS),nasal mucosa recovery,olfactory function,nasal airway resistance,postoperative bleeding and recurrence of the 5 groups of patients were analyzed.Results:(1)On the first postoperative day,self-rating depression scale of group B,C,D and E was lower than that of group A(P<0.05).(2)The VAS score of groups B,C,D and E was lower than that of group A at 1-2 days after surgery(P<0.05),and the VAS score of group E was better than that of group D at 3 days and 1 week after surgery(P<0.05).(3)At 2 weeks after surgery,the Lund-Kennedy score of group B and E was significantly different from those of group C and D(P<0.05).At 1 and 2 months after surgery,the Lund-Kennedy score of group E was lower than that of group C and D respectively(P<0.05).(4)Compared with group A,groups B,C,D and E promoted the recovery of olfactory function in all periods(P<0.05).The recovery of olfactory function in group E was more significant than that in group A,B,C and D at 2 weeks and 2 months after surgery(P<0.05).(5)Compar

关 键 词：慢性鼻窦炎 纳吸棉 布地奈德混悬液 桉柠蒎肠溶软胶囊 

分 类 号：R765.41[医药卫生—耳鼻咽喉科]