营养因素对桥本甲状腺炎患者甲状腺自身抗体滴度的影响  

Association of Nutritional Factors with Thyroid Autoantibody Titer in Hashimoto's Thyroiditis

作　　者：万会娜 张国玉 万红[2] 符宇[2] 王泽瑾 燕树勋[4] 王颖[5] Guoyu;WAN Hong;FU Yu;WANG Zejin;YAN Shuxun;WANG Ying(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China;Endocrinology Ward 2,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Medical College,Hebei University of Engineering,Handan 056000,China;The First Affiliated Hospital of Henan University of Chinese Medicine/Institute of Obesity and Metabolic Diseases of Henan University of Chinese Medicine/Henan Workstation,Hubei Chen's Academic School for Gall Disease Studio,National Administration of Traditional Chinese Medicine,Zhengzhou 450000,China;Department of International Medicine,Zhengdong Branch,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 410105,China)

机构地区：[1]河南中医药大学第一临床医学院,河南省郑州市450000 [2]河南中医药大学第一附属医院内分泌科二病区,河南省郑州市450000 [3]河北工程大学医学院,河北省邯郸市056000 [4]河南中医药大学第一附属医院,河南中医药大学肥胖及代谢病研究所,国家中医药管理局湖北陈氏瘿病学术流派传承工作室河南工作站,河南省郑州市450000 [5]郑州大学第一附属医院郑东院区国际医学部,河南省郑州市410105

出　　处：《中国全科医学》2022年第17期2152-2158,共7页Chinese General Practice

基　　金：河南省科技创新杰出青年支持计划(174100510022);河南省中医药科学研究专项重点课题(20-21ZY1016)。

摘　　要：桥本甲状腺炎(HT)是最常见的自身免疫性甲状腺疾病,也是导致患者甲状腺功能减退(甲减)的最主要因素,甲减会增加患者精神疾病的发病率,甚至会诱发黏液性水肿、昏迷,但有关HT的临床疗法研究目前较少。由于HT患者自身免疫系统紊乱,机体会分泌甲状腺自身抗体,因此甲状腺自身抗体在桥本甲状腺炎的诊断和预后中发挥着重要作用。研究表明,控制营养元素的摄入(如补硒、适碘)对治疗HT具有积极意义,可有效降低甲状腺自身抗体滴度,从而改善患者的甲状腺功能,然而临床对营养因素能否影响HT的治疗尚存争议。本文通过回顾治疗HT的相关研究成果,总结了不同营养因素在HT治疗过程中的作用,发现在治疗HT时,对硒、碘、铁及维生素D等营养因素的调控及干预不仅可发挥降低甲状腺自身抗体滴度的作用,更利于提高治疗HT的效果,能为未来临床治疗HT提供更多参考。As the most common autoimmune thyroid disease,Hashimoto's thyroiditis(HT)is also the primary cause of hypothyroidism,leading to increased risk of mental diseases,and even myxedema and coma.However,there are few studies on clinical treatments for HT.Thyroid autoantibodies produced in serum due to autoimmune disorders,may be significantly involved in the diagnosis and prognosis of HT.Evidence has suggested that the controlling for the intake of nutrient elements(such as appropriate selenium supplementation and iodine intake)may improve thyroid function by notably reducing the thyroid autoantibody titer,indicating the treatment may be positive in treating HT.But the correlations of various nutritional factors with HT treatment are still controversial.We reviewed recent developments in the treatment of HT,then summarized the influence of controlling for the intake of various nutritional factors(such as selenium,iodine,iron and vitamin D)on the treatment of HT,and concluded that the controlling may help to reduce thyroid autoantibody titers,and improve the therapeutic effect,and may be a reference for clinical treatment of HT.

关 键 词：桥本病 营养疗法 自身抗体 影响因素分析 营养因素 抗体滴度 

分 类 号：R581.4[医药卫生—内分泌]